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Pharmacological Implications of Natural Products of Fruits and Vegetable Origin on the Activity of Cytochrome P450 Enzymes

Eugene Ohams Ohanme, Ogbonnaya Nnabuike Iganga, Casimir Chijioke Ofor, Uzochukwu Ofonakara, Amucheukwu Veronica Nwafor, Clementina, Nkiru Eze, Kenneth Eze Etu, Benjamin Nwafocha Nwakelu, Chiazor Prince Unekwe

Asian Journal of Research in Medical and Pharmaceutical Sciences · pp. 54–71 · Published 11 May 2024

10.9734/ajrimps/2024/v13i2255

Abstract

The primary goal of drug metabolism, sometimes referred to as pharmacokinetic process, is to change a medication's chemical structure to make it more readily excretable. Typically, phase I and phase II reactions involve this mechanism. Xenobiotics can stimulate or inhibit the activity of cytochrome P450 (CYP450) enzymes involved in phase I processes. The goal of this research is to clarify the clinical significance of CYP450 induction and inhibition by demonstrating how certain bioactive compounds found in foods or natural products derived from fruits and vegetables can alter CYP450 enzyme activity, impacting drug bioavailability and depuration in addition. The interaction between natural products and foods derived from fruits and vegetables and some pharmaceuticals that can result in toxicity or therapeutic failure will be explained with a few instances. This will make it possible to compile pertinent data regarding appropriate pharmaceutical management in a range of clinical contexts.

Fruits vegetables cytochrome P450 clinical

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