Phytochemical, Nutrient Composition and Serum Lipid Lowering Effect of Xylopia aethiopica Fruit
Yusuf N. Omeh, Samuel O. Onoja, Maxwell I. Ezeja, S. Bassey, G. Ogbenta, Ayoade B. Adetayo
Journal of Pharmaceutical Research International · pp. 2096–2105 · Published 1 Sep 2014
10.9734/BJPR/2014/12392Abstract
Aims: The present study was carried out to evaluate the effects of Xylopia aethiopica on serum lipids in fed rats. Also the quantitative phytochemical and nutrient composition was investigated. Study Design: Quantitative phytochemical, proximate analysis and in vivo effect on serum lipid profile. Place and Duration of Study: Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike Abia State, between June 2013 and September 2013. Methodology: The fruit were cut into small piece, dried and ground into powder. The quantitative phytochemical and proximate nutrient analyses of the powder sample were determined using standard methods. The serum lipid lowering effects of the powdered fruit in rats was determined by feeding different groups of rats with graded levels (5, 10, 20 and 50%) of the powdered fruit incorporated in their feed for 21 consecutive days and the effects on the total cholesterol, triglyceride, LDL-C, and HDL-C were compared with a negative control. Results: The fruit sample produced significant (p<0.05) concentration-dependent decrease in the total serum cholesterol, triglyceride, LDL-C and VLDL-C levels and increase in serum HDL-C level in fed groups of rats when compared to the control group. The phytochemical analysis showed that the sample contained tannins (4.96%), flavonoids (0.81%), saponins (2.93%) and alkaloids (1.24%). The proximate analysis of the nutrient composition of powdered Xylopia aethiopica sample showed the presence of moisture, lipid, crude fibre, crude protein, ash and nitrogen free extracts in the following proportion 6.32, 12.54, 14.51, 0.91, 2.31 and 63.41% respectively. Conclusion: The fruit sample demonstrated good hypolipidemic effects which may suggest that the consumption of Xylopia aethiopica fruit may help in the reduction of the incidence of hyperlipidemia related diseases in patients.
References (28)
- 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
- 2 Global burden of hypertension: analysis of worldwide data [DOI]
- 3 Phytochemical constituents of some Nigerian medicinal plants [DOI]
- 4 The useful plants of West Tropical Africa.
- 5 Clinical Guide to Laboratory Tests. [DOI]
- 6 Dietary Fiber, Glycemic Load, and Risk of Non—insulin-dependent Diabetes Mellitus in Women [DOI]
- 7 A comprehensive evaluation of the heparin–manganese precipitation procedure for estimating high density lipoprotein cholesterol [DOI]
- 8 Studies on phytochemical constituents of six Malaysian medicinal plants [DOI]
- 9 Physical activity and its relationship with obesity, hypertension and diabetes in urban and rural Cameroon [DOI]
- 10 Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats [DOI]
- 11 Colesevelam HCl Improves Glycemic Control and Reduces LDL Cholesterol in Patients With Inadequately Controlled Type 2 Diabetes on Sulfonylurea-Based Therapy [DOI]
- 12 Hypolipidemic activity of seeds of Cassia tora Linn [DOI]
- 13 Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors [DOI]
- 14 Antibacterial and antifungal activity of Xylopia aethiopica, Monodora myristica, Zanthoxylum xanthoxyloıdes and Zanthoxylum leprieurii from Cameroon [DOI]
- 15 Antioxidant and antihyperlipidemic activity of Hibiscus sabdariffa Linn. leaves and calyces extracts in rats.
- 16 Evaluation of acute and subacute toxicity of Alstonia congensis Engler (Apocynaceae) bark and Xylopia aethiopica (Dunal) A. Rich (Annonaceae) fruits mixtures used in the treatment of diabetes [DOI]
- 17 Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models [DOI]
- 18 Nutritional and Phytochemical Screening of Garcinia kola
- 19 Prevalence of Cardiovascular Risk Factors in the Middle-Aged and Elderly Population of a Nigerian Rural Community [DOI]
- 20 Antiproliferative Action of Xylopia aethiopica Fruit Extract on Human Cervical Cancer Cells [DOI]
- 21 Hypolipidemic activity of Sesbania grandiflora in triton wr-1339 induced hyperlipidemic rats
- 22 Investigation of the chemical composition and biological activity of Xylopia aethiopica Dunal (Annonacae) [DOI]
- 23 Anti-hyperlipidemic activity of methanol extracts of three plants of Amaranthus in triton-WR 1339 induced hyperlipidemic rats [DOI]
- 24 Effect of ethanolic fruit extract of Xylopia aethiopica on reproductive function of male rats
- 25 Haematological Properties of Aqueous Extracts of Phyllantus amarus (Schum and Thonn.) and Xylopia aethiopica (Dunal) A. Rich in Albino Rats [DOI]
- 26 Characterization of the Key Aroma Compounds in Dried Fruits of the West African Peppertree Xylopia aethiopica (Dunal) A. Rich (Annonaceae) Using Aroma Extract Dilution Analysis [DOI]
- 27 Comprehensive assessment of the effect of Sphenocentrum jollyanum root extract on male reproductive activity in albino rats [DOI]
- 28 Book Review: Pharmacology by Rang HP, Dale MM, Ritter JM and Moore PK. Fifth edition Churchill Livingstone, Edinburgh, 2003
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