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Research Article Open access CC BY 3.0

Potential Autoepitope within the Extracellular Region of Contactin-Associated Protein-like 2 in Mice

Demian F. Obregon, Yuyan Zhu, Antoinette R. Bailey, Samantha M. Portis, Huayan Hou, Jin Zeng, Saundra L. Stock, Tanya K. Murphy, Michael A. Bengtson, Jun Tan

Journal of Advances in Medicine and Medical Research · pp. 416–432 · Published 28 Sep 2013

10.9734/BJMMR/2014/6135

Abstract

Aims: Implicated in autoimmune encephalitis, neuromyotonia and genetic forms of autism, here we report that contactin-associated protein-like 2 (CNTNAP2) contains a potential autoepitope within the extracellular region. Methodology: CNTNAP2 sequence-similar regions (CSSRs) from human pathogens were identified. Sera from autistic and control children were obtained and analyzed for the presence of antibodies able to bind CSSRs. One such candidate CSSR was evaluated for evidence of autoimmune responses to CNTNAP2 in a mouse model of acute infection. Results: Autistic and control children sera contained antibodies able to discrete regions of CNTNAP2. In a murine model of acute infection, a CSSR derived from the N-terminal extracellular region of CNTNAP2 resulted in anti-CNTNAP2 antibody production, proinflammatory cytokine elevation, cerebellar and cortical white matter T-cell infiltration as well as motor dysfunction. Conclusion: Taken together, these data suggest that CNTNAP2 contains a potential autoepitope within the extracellular region.CNTNAP2;

CNTNAP2 Caspr 2 autoantibody molecular mimicry autoimmune autoepitope autism encephalopathy

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Cited by 2

Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition

Wenjun Liang, Junying Zhang, Margaux Saint-Martin · Journal of Autoimmunity · 2019

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