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Research Article Open access CC BY 3.0

Prenatal Exposure to Maternal Anxiety is Associated with Less Developed Smooth Pursuit Eye Movements in Six-Month-Old Infants: An Initial Study

Laurel Pellegrino, Randal G. Ross, Sharon K. Hunter

International Neuropsychiatric Disease Journal · pp. 89–103 · Published 21 Aug 2013

10.9734/INDJ/2013/5174

Abstract

Aims: There are an increasing number of reports suggesting an association between maternal anxiety experienced during pregnancy and adverse outcomes of the offspring. However, exploration of the biological changes in the brain that mediate that relationship has been hampered by the lack of appropriate biomarkers. This report represents an initial step exploring whether a potential infant biomarker, smooth pursuit eye movements, may be associated with prenatal exposure to maternal anxiety. Study Design: Blinded cross-sectional study. Place and Duration of Study: Department of Psychiatry, University of Colorado School of Medicine. Data collected from July 2011 to May 2012. Methodology: Forty-three infants including 34 whose prenatal maternal anxiety status were identified (12 with a known maternal prenatal anxiety diagnosis and 22 without) had eye movements recorded during a smooth pursuit eye movement task at four and/or six months of age. Results: At 6 months of age, infants with prenatal exposure to maternal anxiety, compared to infants without such exposure, spent a higher percentage of time utilizing smooth pursuit (t=2.7, df=24, P=.013), had longer duration of smooth pursuit uninterrupted by saccades (t=2.5, df=24, P=.019), and had decreased frequency of forward saccades (t=3.8, df=24, P=.001). No differences between groups were identified at 4 months of age. Conclusion: Smooth pursuit abnormalities may, at six months of age, be a potential biomarker for prenatal maternal anxiety exposure.  

Smooth pursuit infants anxiety pregnancy

References (28)

  1. 1 Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years [DOI]
  2. 2 Postnatal disappearance of the pregnancy-associated reduced sensitivity of plasma cortisol to feedback inhibition [DOI]
  3. 3 Stress during pregnancy is associated with developmental outcome in infancy [DOI]
  4. 4 High Antenatal Maternal Anxiety Is Related to ADHD Symptoms, Externalizing Problems, and Anxiety in 8- and 9-Year-Olds [DOI]
  5. 5 Higher Risk of Offspring Schizophrenia Following Antenatal Maternal Exposure to Severe Adverse Life Events [DOI]
  6. 6 Antenatal Maternal Anxiety is Related to HPA-Axis Dysregulation and Self-Reported Depressive Symptoms in Adolescence: A Prospective Study on the Fetal Origins of Depressed Mood [DOI]
  7. 7 Timing of Prenatal Stressors and Autism [DOI]
  8. 8 Prenatal Maternal Anxiety and Depression Predict Negative Behavioral Reactivity in Infancy [DOI]
  9. 9 Cognitive processes involved in smooth pursuit eye movements [DOI]
  10. 10 Development of smooth pursuit tracking in young infants [DOI]
  11. 11 A review on eye movement studies in childhood and adolescent psychiatry [DOI]
  12. 12 Neurophysiology and neuroanatomy of smooth pursuit in humans [DOI]
  13. 13 Eye-Tracking Dysfunctions in Schizophrenic Patients and Their Relatives [DOI]
  14. 14 AN EXPERIMENTAL STUDY OF THE OCULAR REACTIONS OF THE INSANE FROM PHOTOGRAPHIC RECORDS. [DOI]
  15. 15 Development of fetal movement — fetal heart rate coupling from 20 weeks through term [DOI]
  16. 16 Prenatal predictors of infant temperament [DOI]
  17. 17 Automated Corneal‐Reflection Eye Tracking in Infancy: Methodological Developments and Applications to Cognition [DOI]
  18. 18 Eye movement impairments in Parkinson's disease: possible role of extradopaminergic mechanisms [DOI]
  19. 19 The development of reactive saccade latencies [DOI]
  20. 20 Maternal anxiety during pregnancy: effect on fetal behavior at 38 to 40 weeks of gestation.
  21. 21 Pursuit tracking impairments in schizophrenia and mood disorders: step-ramp studies with unmedicated patients [DOI]
  22. 22 The effect of apomorphine administration on smooth pursuit ocular movements in early Parkinsonian patients [DOI]
  23. 23 Smooth pursuit in infants: maturation and the influence of stimulation [DOI]
  24. 24 Development of visual pursuit in the first 6 years of life [DOI]
  25. 25 Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia [DOI]
  26. 26 Early Expression of a Pathophysiological Feature of Schizophrenia: Saccadic Intrusions Into Smooth-Pursuit Eye Movements in School-Age Children Vulnerable to Schizophrenia [DOI]
  27. 27 Pursuit eye movement dysfunction in obsessive-compulsive disorder [DOI]
  28. 28 The development of visual pursuit during the first months of life [DOI]

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