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Research Article Open access CC BY 3.0

Preparation and Characterization of Polymeric Mucoadhesive Film for Buccal Administration

Ramy B. Gales, Hassan M. Ghonaim, Ahmed R. Gardouh, Mamdouh M. Ghorab, Sabry S. Badawy

Journal of Pharmaceutical Research International · pp. 453–476 · Published 24 Dec 2013

10.9734/BJPR/2014/5399

Abstract

Objectives: Buccal films consist mainly of polymer that has a good mucoadhesive profile and plasticizer. A lot of polymers and plasticizers can be used to configure the mucoadhesive films as hydroxyethyl cellulose and glycerin respectively. Material and Methods: Films prepared by dispersing the polymer, mixing it with plasticizer and pouring it in Petri dishes to be dried and cut finally. Physicochemical tests were used to evaluate the films. These tests are organoleptic evaluation and polymer and plasticizer selection, determination of rheological properties of polymers, film thickness, and determination of moisture content, determination of moisture uptake and evaluation of mechanical properties. Results and Conclusions: It was found that films prepared from polyvinyl alcohol 2% (w/w) especially with the addition of propylene glycol 20% from the weight of the polymer have excellent characteristics. This formula has promising organoleptic and mechanical properties and its solution is Non-Newtonian pseudoplastic. Moreover, this formula is very thin and has moderate percent of moisture content and moisture uptake. Also, it has high elongation with moderate tensile strength. As a result, it is better to prepare the film by these ingredients to obtain an ideal mucoadhesive formula.

Organoleptic evaluation rheological properties mechanical properties propylene glycol mucoadhesive film.

References (44)

  1. 1 Handbook of Pharmaceutical Excipients
  2. 2 Mucoadhesive drug delivery systems [DOI]
  3. 3 Present and future applications of biomaterials in controlled drug delivery systems [DOI]
  4. 4 Water sorption and mechanical properties of cassava starch films and their relation to plasticizing effect [DOI]
  5. 5 Rheological properties of carboxymethyl cellulose (CMC) solutions [DOI]
  6. 6 Plasticizer effect on mechanical properties of β-lactoglobulin films [DOI]
  7. 7 Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound dressing.
  8. 8 Permeability and Mechanical Properties of Cellulose‐Based Edible Films [DOI]
  9. 9 Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing [DOI]
  10. 10 Composition Factors Affecting the Water Vapor Permeability and Tensile Properties of Hydrophilic Films [DOI]
  11. 11 Formulation of a Novel Tianeptine Sodium Orodispersible Film [DOI]
  12. 12 Formulation and Evaluation of Buccal Patches for Delivery of Atenolol [DOI]
  13. 13 Water content of ambient aerosol during the Pittsburgh Air Quality Study [DOI]
  14. 14 Network Structure of Cellulose Ethers Used in Pharmaceutical Applications During Swelling and at Equilibrium [DOI]
  15. 15 Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part I: Physicochemical Evaluation [DOI]
  16. 16 Formulation and evaluation of mucoadhesive buccal films of enalapril maleate [DOI]
  17. 17 Rheological characterisation of primary and binary interactive bioadhesive gels composed of cellulose derivatives designed as ophthalmic viscosurgical devices [DOI]
  18. 18 Water‐Soluble Polymer Applications in Foods [DOI]
  19. 19 Blends of aqueous polymer dispersions used for pellet coating: Importance of the particle size [DOI]
  20. 20 Influence of plasticizer molecular weight on plasticizer retention in PVC geomembranes [DOI]
  21. 21 Preparation and evaluation of ciprofloxacin loaded chitosan-gelatin composite films for wound healing activity. [DOI]
  22. 22 Formulation and evaluation of nitrendipine buccal films [DOI]
  23. 23 Development of Mucoadhesive Buccal Films of Glipizide [DOI]
  24. 24 Physical–mechanical, moisture absorption and bioadhesive properties of hydroxypropylcellulose hot-melt extruded films [DOI]
  25. 25 Water-Sorption Properties of Tablet Disintegrants [DOI]
  26. 26 Sorption and wetting properties of pectin edible films [DOI]
  27. 27 FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF GLIBENCLAMIDE [DOI]
  28. 28 Evaluation of surface and microstructure of differently plasticized chitosan films [DOI]
  29. 29 Edible Films Prepared from Water Extract of Soybeans [DOI]
  30. 30 FORMULATION AND EVALUATION OF BUCCAL PATCHES OF VENLAFAXINE
  31. 31 Development of domperidone bilayered matrix type transdermal patches: physicochemical, in vitro and ex vivo characterization.
  32. 32 Effect of PVA functionalization on hydrophilicity of Y-junction single wall carbon nanotubes [DOI]
  33. 33 Intraoral Delivery Systems [DOI]
  34. 34 Effects of propylene glycol on the physical properties of poly(vinyl alcohol) solutions and films [DOI]
  35. 35 Rheology of pharmaceutical and cosmetic semisolids.
  36. 36 The rheology of pharmaceutical and cosmetic semisolids
  37. 37 Development and Physiochemical, In-Vitro Evaluation of Antihypertensive Transdermal Patches
  38. 38 Formulation and Evaluation of Mucoadhesive Buccal Patches of Aceclofenac
  39. 39 Biodegradable Films from Pectin-Starch and Pectin-Poly(vinyl alcohol) [DOI]
  40. 40 DESIGN AND EVALUATION OF PECTIN BASED MATRIX FOR TRANSDERMAL PATCHES OF MELOXICAM
  41. 41 DESIGN, DEVELOPMENT AND EVALUATION OF MUCCOADHESIVE PATCHES OF NIFEDIPINE FOR BUCCAL DELIVERY
  42. 42 Viscosity sinergism of hydrozypropmethyl and carboxy methyl cellulose [DOI]
  43. 43 Peptides and Proteins: Buccal Absorption [DOI]
  44. 44 Mechanical properties of biopolymer films

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