Skip to content
Research Article Open access CC BY 3.0

Preparation and Evaluation of Novel Expandable Drug Delivery System

D. Sathish, S. Himabindu, P. Pavan Kumar, Y. Madhusudan Rao

Journal of Pharmaceutical Research International · pp. 1079–1093 · Published 29 Aug 2013

10.9734/BJPR/2013/4891

Abstract

Aims: The purpose of this research is to develop a novel expandable gastroretentive dosage form (GRDF), based on unfolding mechanism. It consists of a drug loaded bilayer polymeric film, folded into a hard gelatin capsule. Gastric retention is achieved due to unfolding of the dosage form within 15-20 min. Furosemide is selected as the drug candidate for this work. Due to its narrow absorption window, Furosemide has to be administered to the upper parts of the intestine in order to maintain sustained therapeutic levels. This may be achieved by a GRDF. Methodology: Films were prepared by solvent-casting technique using Ethyl cellulose, HPMC E15 and Eudragit RLPO as polymers and dibutyl phthalate as the plasticizer in both layers. The film with zigzag folding in the capsule was shown to unfold in the gastric juice and provide drug release up to 12 h in the acidic medium. The films were evaluated for weight & thickness variation, mechanical properties, in vitro drug release and unfolding behavior based on the mechanical shape memory of polymers. Absence of drug polymer interaction and uniform drug dispersion in the polymeric layers was revealed by DSC, XRD studies and SEM. The GRDF location in the gastrointestinal tract was determined by X-ray studies. Results: X-ray studies revealed that the GRDF is retained in the stomach up to 6± 0.5 h in fasting condition and 8 h in fed state. Conclusion: The polymers used in the development of GRDFs were safe and proper combination of these polymers will yield a novel expandable GRDF with good in vitro drug release in acidic media, mechanical properties, and unfolding behaviour. These outcomes demonstrate that the GRDF may be used to improve furosemide therapy and can be applied to extend the absorption of other narrow absorption window drugs that require continuous input.

Furosemide expandable drug delivery systems gastric retention mechanical properties hydroxy propyl methyl cellulose ethyl cellulose

References (9)

  1. 1 Expandable gastroretentive dosage forms [DOI]
  2. 2 Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Furosemide [DOI]
  3. 3 Novel Gastroretentive Dosage Forms: Evaluation of Gastroretentivity and Its Effect on Riboflavin Absorption in Dogs [DOI]
  4. 4 Gastroretentive Dosage Forms for Prolonging Gastric Residence Time [DOI]
  5. 5 Rediguieri CF, Porta V, Nunes DSG, Nunes TM, Junginger HE, Kopp S, Midha KK, Shah VP, Stavchansky S, Dressman JB, Barends DM. 2011. Biowaiver monographs for immediate‐release solid oral dosage forms: Metronidazole. J Pharm Sci 100:1618–1627. [DOI]
  6. 6 Novel Gastroretentive Dosage Forms: Evaluation of Gastroretentivity and Its Effect on Levodopa Absorption in Humans [DOI]
  7. 7 Floating Drug Delivery Systems for Prolonging Gastric Residence Time: A Review [DOI]
  8. 8 Some aspects of the photochemical degradation of frusemide.
  9. 9 Martindale: the complete drug reference [DOI]

Cited by 16

Novel expandable gastro retentive system by unfolding mechanism of levetiracetam using simple lattice design – Formulation optimization and in vitro evaluation

S. Sivaneswari, E. Karthikeyan, P.J. Chandana · Bulletin of Faculty of Pharmacy, Cairo University · 2017

Formulation and <i>In Vitro </i>Evaluation of Gastroretentive Theophylline Floating Tablets

D.Nagasamy Venkatesh, Raman Rajeshkumar, Roan Ngoc Anh Huy · Materials Science Forum · 2020

Foldable/Expandable Gastro-retentive Films Based on Starch and Chitosan as a Carrier For Prolonged Release of Resveratrol

Rattakorn Boontawee, Ousanee Issarachot, Kanidta Kaewkroek · Current Pharmaceutical Biotechnology · 2022

Administration strategies and smart devices for drug release in specific sites of the upper GI tract

Marco Uboldi, Alice Melocchi, Saliha Moutaharrik · Journal of Controlled Release · 2022

Development of Novel Unfolding Film System of Itopride Hydrochloride Using Box-Behnken Design—A Gastro Retentive Approach

Shaima Alaithan, Nimbagal Raghavendra Naveen, Prakash S. Goudanavar · Pharmaceuticals · 2022

Novel Swellable/Expandable Gastroretentive Floating Films of Gliclazide Folded in Capsule Shell for the Effective Management of Diabetes Mellitus: Formulation Development, Optimization and In Vitro Evaluation

Diksha Sharma, Deepak Sharma · Current Drug Therapy · 2021

Showing 6 of 16 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

12

Page views

0

PDF downloads

1

Outbound clicks

16

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.