Primary Testicular Lymphoma: A Study of  11 Cases

H. Regaieg; N. Ben Sayed; Y. Ben Youssef; B. Achour; S. Hmissa; H. El Omri; A. Khelif

doi:10.9734/IBRR/2014/10504

Research Article Open access CC BY 3.0

Primary Testicular Lymphoma: A Study of 11 Cases

H. Regaieg, N. Ben Sayed, Y. Ben Youssef, B. Achour, S. Hmissa, H. El Omri, A. Khelif

International Blood Research & Reviews · pp. 213–221 · Published 4 Jun 2014

10.9734/IBRR/2014/10504

Abstract

Primary testicular lymphoma (PTL) is an uncommon extranodal presentation constituting 1% of all NHL and 5% of all testicular neoplasm. The objective of our study was to identify the presenting signs and symptoms, treatment and outcome of patients with testicular lymphoma diagnosed at the Hematology department of Farhat Hached University Hospital from 1997 to 2007 and to perform bibliography review about this pathology. Eleven cases were identified; the median age was 61 years (range:31-83). All patients presented with testicular and scrotal swelling or mass. B symptoms (recurrent fever of>38ºC temperature, night sweets and unexplained weight loss of>10% of the body weight within six months prior to diagnosis) were present in 6 patients. According to the "Ann-Arbor staging system", 7 patients were classified stage IE( involving a single lymph node region (I) or single extralymphatic organ or site) and IIE (two or more involved lymph node regions on the same side of the diaphragm (II) or localized involvement of an extralymphatic organ or site), 4 patients were classified stage IVE (the presence of diffuse or disseminated involvement of one or more extralymphatic organs (e.g., liver, bone, marrow, lung), with or without associated lymph node involvement). International Prognostic index was low (<2) in 7 patients and high (≥2) in 4 cases. Orchidectomy was performed in all cases. Eight patients received chemotherapy based on COP (2cases), mini CEOP (3 cases), ACVBP (2 cases). Eight patients received central nervous system prophylaxis in the form of intrathecal methotrexate. Radiation at the dose of 40Gy was given to 3 patients. Three patients achieved complete remission. Two patients relapsed. The median survival was 3 months (range: 1 week-107 months). Testicular lymphoma is a rare and deadly form of extra nodal lymphoma, randomized prospective treatment trials may help to establish better treatment strategies.

Primary testicular lymphoma treatment prognosis outcome

References (14)

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H. Regaieg, N. Ben Sayed, Y. Ben Youssef, B. Achour, S. Hmissa, H. El Omri, A. Khelif (2014). Primary Testicular Lymphoma: A Study of 11 Cases. International Blood Research & Reviews , 213–221. https://doi.org/10.9734/IBRR/2014/10504

Affiliations

H. Regaieg — Department of Clinical Hematology, Farhat Hached Hospital, Sousse, Tunisia
N. Ben Sayed — Department of Clinical Hematology, Farhat Hached Hospital, Sousse, Tunisia
Y. Ben Youssef — Department of Clinical Hematology, Farhat Hached Hospital, Sousse, Tunisia
B. Achour — Department of Clinical Hematology, Farhat Hached Hospital, Sousse, Tunisia
S. Hmissa — Department of Pathology, Farhat Hached Hospital, Sousse, Tunisia
H. El Omri — Department of Clinical Hematology, Farhat Hached Hospital, Sousse, Tunisia
A. Khelif — Department of Clinical Hematology, Farhat Hached Hospital, Sousse, Tunisia

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