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Research Article Open access CC BY 3.0

Regulation of TSH Receptor Autoantibodies by a long Non-Coding RNA (Heg) and Cdk1- A Review

Niels Juel Christensen, Gurli Habekost, Palle Bratholm

Journal of Advances in Medicine and Medical Research · pp. 508–516 · Published 27 Feb 2013

10.9734/BJMMR/2013/2616

Abstract

Aims: A substantial part of the genome is transcribed in non-coding RNAs. We review our finding of a long non-coding RNA (designated Heg) in mononuclear cells (MNC) and regulation of TSH receptor autoantibodies (TRAb). Results: The Heg RNA transcript in MNC is negatively correlated with TRAb in patients with early and untreated Graves’ disease. In treated patients and in controls Heg correlated negatively with CD14 mRNA. Transfection studies with fragments of Heg added to MNC (exogenous Heg) decreased CD14 mRNA in MNC and increased gene expression of RIG-I, TLR7 and IFN-γ. Heg is likely to activate TLR7 receptors. CD14 is a co-receptor of TLR7. Decrease in gene expression of CD14 after Heg is a sign of differentiation of MNC to dendritic cells. This may reduce surface expression of CD14, cytokine responses and the responsiveness to TSH receptor antigens. Thus the relationship between TRAb and lnc Heg RNA is most likely explained by receptor cross-interference. Cdk1 mRNA (an index of cell cycle activity) is positively related with TRAb. Cdk1mRNA and TRAb but not Heg decreased significantly during antithyroid treatment. Cdk1 decreased to values below normal. Conclusion: Thus both Heg RNA and Cdk1 may regulate the level of TRAb but by two different mechanisms.

Antithyroid drugs autoimmunity CD14 Cdk1 receptor cross-interference long non-coding Heg RNA TSH receptor autoantibodies

References (26)

  1. 1 Evolution and Functions of Long Noncoding RNAs [DOI]
  2. 2 Non-coding RNAs in human disease [DOI]
  3. 3 Modular regulatory principles of large non-coding RNAs [DOI]
  4. 4 Cdk1 is sufficient to drive the mammalian cell cycle [DOI]
  5. 5 Regulation of cytoplasmic mRNA decay [DOI]
  6. 6 Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation [DOI]
  7. 7 Nucleic Acid Recognition by the Innate Immune System [DOI]
  8. 8 IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA [DOI]
  9. 9 Genetic variation in Toll-like receptors and disease susceptibility [DOI]
  10. 10 The etiology of autoimmune thyroid disease: A story of genes and environment [DOI]
  11. 11 CD14 is a coreceptor of Toll-like receptors 7 and 9 [DOI]
  12. 12 Circulating MicroRNA Profiles as Potential Biomarkers for Diagnosis of Papillary Thyroid Carcinoma [DOI]
  13. 13 Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses [DOI]
  14. 14 Decapping of Long Noncoding RNAs Regulates Inducible Genes [DOI]
  15. 15 Cutting Edge: The Etiology of Autoimmune Thyroid Diseases [DOI]
  16. 16 Distinct RNA degradation pathways and 3' extensions of yeast non-coding RNA species [DOI]
  17. 17 Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo [DOI]
  18. 18 Epigenotype switching at the CD14 and CD209 genes during differentiation of human monocytes to dendritic cells [DOI]
  19. 19 Long noncoding RNAs: the search for function [DOI]
  20. 20 MicroRNAs miR-146a1, miR-155_2, and miR-200a1 Are Regulated in Autoimmune Thyroid Diseases [DOI]
  21. 21 The search for the genetic contribution to autoimmune thyroid disease: the never ending story? [DOI]
  22. 22 A RNA transcript (Heg) in mononuclear cells is negatively correlated with CD14 mRNA and TSH receptor autoantibodies [DOI]
  23. 23 CD14+ cells are required for IL-12 response in bovine blood mononuclear cells activated with Toll-like receptor (TLR) 7 and TLR8 ligands [DOI]
  24. 24 Decrease in TSH Receptor Autoantibodies during Antithyroid Treatment: Relationship with a Long Noncoding Heg RNA and Cdk1 mRNA in Mononuclear Cells [DOI]
  25. 25 Beta2-adrenoceptor desensitization in non-pregnant estrogen-primed rat myometrium involves modulation of oxytocin receptor gene expression [DOI]
  26. 26 Genome-wide analysis of long noncoding RNA stability [DOI]

Cited by 2

Heg lnc RNA and Cdk1 mRNA in mononuclear cells and regulation of autoantibody levels

Niels Juel Christensen · MOJ Drug Design Development & Therapy · 2018

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