Review of Experimental Models of Schizophrenia
Bushra Naz, Prabhat Singh, Simon Nyarko, Ramzan Ali Banjara
International Neuropsychiatric Disease Journal · pp. 1–19 · Published 5 Jan 2023
10.9734/indj/2023/v19i1362Abstract
Schizophrenia is a severe psychiatric disease that has a lifetime prevalence of 1% in most of the populations studied. The neuropathology and psychopathology of Schizophrenia are still poorly understood. This is attributed to the paucity of adequate animal models. Schizophrenia is a disorder of the human brain. Consequently, the potency of animal models in Schizophrenia research is limited to certain aspects of the disease. One of the most difficult aspects of modelling Schizophrenia in animals has been the lack of a clear and explicit conceptual framework for this disorder. This review discussed drug-induced animal models of Schizophrenia such as Ketamine (NMDA receptor antagonist), Phencyclidine (NMDA receptor antagonist) etc. It also discussed genetic animal models of Schizophrenia which include but not limited to Schizophrenia susceptibility Genes, Neuregulin-1(NRG1), DAT gene, Zinc finger DHH-type3 containing 8 (ZDHHC8) and Dysbindin. It went further to discuss fetal models Schizophrenia, postweaning social isolation and ended with In-Vitro animal models. The use of animal models to improve understanding of the neurochemical and structural CNS changes that precipitate development of Schizophrenia, rather than a focus on treating the symptoms, is a prerequisite to enable new more effective therapeutic strategies to be developed. Because of the complexity and ambiguity of gene-gene and gene-environment interactions in the aetiology of schizophrenia, the challenge of developing more reliable predictive animal models of this disorder, most likely through multiple early-life interventions, is still ongoing.
References (91)
- 1 Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans [DOI]
- 2 Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies [DOI]
- 3 Neuregulin 1 in neural development, synaptic plasticity and schizophrenia [DOI]
- 4 Identification of PSD-95 Palmitoylating Enzymes [DOI]
- 5 Ketamine-induced changes in rat behaviour: A possible animal model of schizophrenia [DOI]
- 6 Phencyclidine animal models of schizophrenia: Approaches from abnormality of glutamatergic neurotransmission and neurodevelopment [DOI]
- 7 M 4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related central nervous system pathologies [DOI]
- 8 The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo [DOI]
- 9 The possible role of the Akt signaling pathway in schizophrenia [DOI]
- 10 Comparison of the effects of acute and chronic administration of ketamine on hippocampal oscillations: relevance for the NMDA receptor hypofunction model of schizophrenia [DOI]
- 11 Developmental vitamin D deficiency alters dopamine-mediated behaviors and dopamine transporter function in adult female rats [DOI]
- 12 Slitrks as emerging candidate genes involved in neuropsychiatric disorders [DOI]
- 13 Phenotypic Characterization of Transgenic Mice Overexpressing Neuregulin-1 [DOI]
- 14 Magnesium sulfate reduces inflammation-associated brain injury in fetal mice [DOI]
- 15 Reelin and its complex involvement in brain development and function [DOI]
- 16 BDNF–TrkB signaling and neuroprotection in schizophrenia [DOI]
- 17 Functional Polymorphisms in PRODH Are Associated with Risk and Protection for Schizophrenia and Fronto-Striatal Structure and Function [DOI]
- 18 Consequences of early life MK-801 administration: Long-term behavioural effects and relevance to schizophrenia research [DOI]
- 19 Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor‐activated trafficking of the dopamine transporter [DOI]
- 20 NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia [DOI]
- 21 Modeling cholinergic aspects of schizophrenia: Focus on the antimuscarinic syndrome [DOI]
- 22 Behavioral Phenotypes in Schizophrenic Animal Models With Multiple Combinations of Genetic and Environmental Factors [DOI]
- 23 Intrinsic sensory deprivation induced by neonatal capsaicin treatment induces changes in rat brain and behaviour of possible relevance to schizophrenia [DOI]
- 24 Inhibition of the l-arginine–nitric oxide pathway mediates the antidepressant effects of ketamine in rats in the forced swimming test [DOI]
- 25 Preclinical models of antipsychotic drug action [DOI]
- 26 Schizophrenia susceptibility and NMDA-receptor mediated signalling: an association study involving 32 tagSNPs of DAO, DAOA, PPP3CC, and DTNBP1genes [DOI]
- 27 Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors [DOI]
- 28 Phencyclidine decreases tickling-induced 50-kHz ultrasound vocalizations in juvenile rats [DOI]
- 29 Low trihalomethane formation in Korean drinking water [DOI]
- 30 Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study [DOI]
- 31 Nitric oxide modulates apomorphine-induced recognition memory deficits in rats [DOI]
- 32 DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis [DOI]
- 33 Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion [DOI]
- 34 The Melanin-Concentrating Hormone (MCH) System Modulates Behaviors Associated with Psychiatric Disorders [DOI]
- 35 Chronic ketamine produces altered distribution of parvalbumin-positive cells in the hippocampus of adult rats [DOI]
- 36 The spatio-temporal expression of MHC class I molecules during human hippocampal formation development [DOI]
- 37 The Schizophrenia and Bipolar Disorder associated BRD1 gene is regulated upon chronic restraint stress [DOI]
- 38 Reversal of scopolamine-induced disruption of prepulse inhibition by clozapine in mice [DOI]
- 39 Reproducibility of Post-Amphetamine [11C]FLB 457 Binding to Cortical D2/3 Receptors [DOI]
- 40 Contribution of nonprimate animal models in understanding the etiology of schizophrenia [DOI]
- 41 Evidence for impaired sound intensity processing during prepulse inhibition of the startle response in a rodent developmental disruption model of schizophrenia [DOI]
- 42 Differential effects of estrogen and testosterone on auditory sensory gating in rats [DOI]
- 43 Prepubertal chronic stress and ketamine administration to rats as a neurodevelopmental model of schizophrenia symptomatology [DOI]
- 44 The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice [DOI]
- 45 Altered netrin‐1 receptor expression in dopamine terminal regions following neonatal ventral hippocampal lesions in the rat [DOI]
- 46 Association study of bromodomain‐containing 1 gene with schizophrenia in Japanese population [DOI]
- 47 Short CAG repeats within the hSKCa3 gene associated with schizophrenia [DOI]
- 48 Opposite effects of neonatal hypoxia on acute amphetamine-induced hyperlocomotion in adult and adolescent mice [DOI]
- 49 Nerve growth factor and brain-derived neurotrophic factor concentrations in schizophrenia: a review.
- 50 Letter to the Editor: Backbone 1H, 13C and 15N resonance assignments for the 25.8 kDa DNA binding domain of the human p63 protein [DOI]
- 51 Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia [DOI]
- 52 Vanilloid (Capsaicin) Receptors and Mechanisms [DOI]
- 53 The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway [DOI]
- 54 Maternal Influenza Infection Causes Marked Behavioral and Pharmacological Changes in the Offspring [DOI]
- 55 Dopaminergic foundations of schizotypy as measured by the German version of the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE)—a suitable endophenotype of schizophrenia [DOI]
- 56 Genetics of bipolar disorder [DOI]
- 57 Hypothesis: Is low prenatal vitamin D a risk-modifying factor for schizophrenia? [DOI]
- 58 Association Between Prenatal Exposure to Bacterial Infection and Risk of Schizophrenia [DOI]
- 59 An Overview of Animal Models Related to Schizophrenia [DOI]
- 60 miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non–Small Cell Lung Cancer [DOI]
- 61 Incidental Colonic Focal Lesions Detected by FDG PET/CT [DOI]
- 62 Effects of maternal immune activation on gene expression patterns in the fetal brain [DOI]
- 63 Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia [DOI]
- 64 The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity [DOI]
- 65 Immature Dentate Gyrus: An Endophenotype of Neuropsychiatric Disorders [DOI]
- 66 The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development [DOI]
- 67 Evidence for association of hyperprolinemia with schizophrenia and a measure of clinical outcome [DOI]
- 68 The Role of the Major Histocompatibility Complex Region in Cognition and Brain Structure: A Schizophrenia GWAS Follow-Up [DOI]
- 69 Neurobehavioral and Immunological Consequences of Prenatal Immune Activation in Rats. Influence of Antipsychotics [DOI]
- 70 Differential Effects of Direct and Indirect Dopamine Agonists on Prepulse Inhibition: A Study in D1 and D2 Receptor Knock-Out Mice [DOI]
- 71 Kynurenine Pathway in Schizophrenia: Pathophysiological and Therapeutic Aspects [DOI]
- 72 DTNBP1 (Dysbindin) Gene Variants Modulate Prefrontal Brain Function in Healthy Individuals [DOI]
- 73 Pain insensitivity in the relatives of schizophrenia patients [DOI]
- 74 The niacin skin flush abnormality in schizophrenia: a quantitative dose–response study [DOI]
- 75 Dysbindin-Containing Complexes and their Proposed Functions in Brain: From Zero to (too) Many in a Decade [DOI]
- 76 Nogo Receptor 1 (RTN4R) as a Candidate Gene for Schizophrenia: Analysis Using Human and Mouse Genetic Approaches [DOI]
- 77 Unraveling Monoamine Receptors Involved in the Action of Typical and Atypical Antipsychotics on Glutamatergic and Serotonergic Transmission in Prefrontal Cortex [DOI]
- 78 A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia [DOI]
- 79 BDNF and TrkB protein expression is altered in the fetal hippocampus but not cerebellum after chronic prenatal compromise [DOI]
- 80 A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval [DOI]
- 81 Coupling of gene expression in medial prefrontal cortex and nucleus accumbens after neonatal ventral hippocampal lesions accompanies deficits in sensorimotor gating and auditory processing in rats [DOI]
- 82 Co-occurrence of affective and schizophrenia spectrum disorders with PINK1 mutations [DOI]
- 83 Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal [DOI]
- 84 Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review [DOI]
- 85 Physiologically based pharmacokinetic model of midazolam disposition during pregnancy [DOI]
- 86 D-Amphetamine and Antipsychotic Drug Effects on Latent Inhibition in Mice Lacking Dopamine D2 Receptors [DOI]
- 87 The effects of a DTNBP1 gene variant on attention networks: an fMRI study [DOI]
- 88 At Issue: The Problem of Obstetrical Complications and Schizophrenia [DOI]
- 89 CAG‐Repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: A meta‐analysis of association studies [DOI]
- 90 Effects of AS2586114, a soluble epoxide hydrolase inhibitor, on hyperlocomotion and prepulse inhibition deficits in mice after administration of phencyclidine [DOI]
- 91 Antidopam inergic effects of leucine and genistein on shizophrenic rat models [DOI]
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