Review on Simultaneous Estimation of Metformin Hydrochloride, Empagliflozin, Linagliptin

Abstract

Sodium glucose co-transporter-2(Sglt-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors and biguanides are the agents which are defined as the anti-diabetic agents used in treatment of type 2 Diabetes Mellitus. Metformin Hydrochloride, linagliptin, empagliflozin, are the drugs of the class mentioned. Objective: The aim is to provide the information of the different analytical methods used in the estimation of these drugs.Since most of the patients are unable to maintain their glucose levels by only a single drug a combination of one/ more drug has been used inorder to maintain the diabetes The present review provides information on various simultaneous estimation to determine the three drugs in combination [trijardy xr] and either of the drugs in the pharmaceutical preparations.The literature survey focused on the analytical methods for the estimation of the drugs individually and also in combination by QBD, RP-UPLC,RPHPLC,UPLC,HPTLC, LC-TMS,UV were performed and repoted. Conclusion: People who take the drugs can receive the same treatment in a single combination tablet. The single pill combination may also simplify the potential therapy and it also improve the clinical outcmes when it is compared with the administration of a single tablet.