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Research Article Open access CC BY 3.0

Role of 3D FLAIR in Demonstration of Peripheral Lesions of Brainstem and Cranial Neuropathies

Graeme MacKenzie, Avinash Kumar Kanodia, Pheyming Yeap, Jonathan O. Riordan, Richard Stephen Nicholas, Gavin Main

International Neuropsychiatric Disease Journal · pp. 167–174 · Published 25 Feb 2014

10.9734/INDJ/2014/8190

Abstract

Aim: We present a pictorial review of 3D FLAIR images depicting its importance in demonstrating the peripheral lesions of brainstem particularly in relation to attachment of cranial nerves and cranial neuropathies and particularly in context of patients with multiple sclerosis (MS). Discussion: T2 axials and routine 2D FLAIR have drawbacks in depicting the lesions on the peripheral aspects of brainstem. Such lesions are commonly found in MS. The revised McDonald’s criteria (2010) put equal emphasis on periventricular, juxtacortical, infratentorial and cord lesions. Detection of peripheral lesions thus play important role in fulfilling the criteria of dissemination in space and also provide anatomic correlate in several cranial nerve palsies. In clinically isolated syndromes, demonstration of lesions at the site of affected cranial nerves increase diagnostic confidence and exclude other potential disease processes. Ability to show signal changes at cranial nerve attachment can also potentially prevent a false attribution of symptoms to neurovascular compression. Conclusion: We propose that 3D FLAIR sequence is extremely useful in detecting abnormalities on the surface of brainstem and cranial nerve attachments and should be performed in all patients of MS and cranial nerve palsies.  

Multiple sclerosis 3D FLAIR cranial nerve palsies

References (11)

  1. 1 Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria [DOI]
  2. 2 Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis [DOI]
  3. 3 Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria” [DOI]
  4. 4 Comparison of flow artifacts between 2D-FLAIR and 3D-FLAIR sequences at 3�T [DOI]
  5. 5 Suppression of Cerebrospinal Fluid and Blood Flow Artifacts in FLAIR MR Imaging with a Single-Slab Three-dimensional Pulse Sequence: Initial Experience [DOI]
  6. 6 Central trigeminal involvement in multiple sclerosis using high-resolution MRI at 3 T [DOI]
  7. 7 Comparison of 3D FLAIR, 2D FLAIR, and 2D T2-Weighted MR Imaging of Brain Stem Anatomy [DOI]
  8. 8 3D FLAIRED: 3D fluid attenuated inversion recovery for enhanced detection of lesions in multiple sclerosis [DOI]
  9. 9 Three-dimensional fast fluid attenuated inversion recovery (3D fast FLAIR): a new MRI sequence which increases the detectable cerebral lesion load in multiple sclerosis. [DOI]
  10. 10 Multiple sclerosis: a consideration in acute cranial nerve palsies.
  11. 11 Glossopharyngeal neuralgia secondary to vascular compression in a patient with multiple sclerosis: a case report [DOI]

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