Role of Zinc in an Organism and Its Influence on Processes Leading to Apoptosis
Journal of Advances in Medicine and Medical Research · pp. 239–305 · Published 28 Jul 2011
10.9734/BJMMR/2011/488Abstract
This review brings together and analyzes the problem of zinc effects on the body through apoptosis, also affecting the latest data in the study of process itself apoptosis. Also, the possibility of using zinc and its derivatives and its complexes in cancer treatment are discussed. The review also focuses on the biochemical problems that lead to various diseases occurring in conditions of excess or deficiency of intracellular zinc. Review includes more than 300 references and contains research over the past ~ 15 years, focusing on the latest data.
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- 194 The molecular mechanisms of neuronal apoptosis [DOI]
- 195 Trace elements and antioxidant enzymes in extremely low birthweight infants [DOI]
- 196 Zinc has ambiguous effects on chromium (VI)-induced oxidative stress and apoptosis [DOI]
- 197 Zinc protects human peripheral blood lymphocytes from Cr(III)(phenanthroline)3-induced apoptosis [DOI]
- 198 The Golgi apparatus of moptor neurons in amyotrophic lateral sclerosis [DOI]
- 199 Single Mutation Induces a Metal-Dependent Subunit Association in Dimeric Cu,Zn Superoxide Dismutase [DOI]
- 200 Expression of metallothionein mRNAs on mouse cerebellum microglia cells by thimerosal and its metabolites [DOI]
- 201 Inflamm‐aging: An Evolutionary Perspective on Immunosenescence [DOI]
- 202 Regulation Mechanisms and Signaling Pathways of Autophagy [DOI]
- 203 The ubiquitin–proteasome pathway: on protein death and cell life [DOI]
- 204 Metallothionein: the multipurpose protein [DOI]
- 205 How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? [DOI]
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- 207 A novel gene involved in zinc transport is deficient in the lethal milk mouse [DOI]
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- 209 Brain, aging and neurodegeneration: Role of zinc ion availability [DOI]
- 210 Metallothioneins: unparalleled diversity in structures and functions for metal ion homeostasis and more [DOI]
- 211 Functional Characterization of a Novel Mammalian Zinc Transporter, ZnT6 [DOI]
- 212 Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion [DOI]
- 213 “Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology [DOI]
- 214 Hyperosmotic stress induces metacaspase‐ and mitochondria‐dependent apoptosis in Saccharomyces cerevisiae [DOI]
- 215 Oxidative stress and brain aging: is zinc the link? [DOI]
- 216 Metal ionophores – An emerging class of anticancer drugs [DOI]
- 217 Oxidized/misfolded superoxide dismutase‐1: the cause of all amyotrophic lateral sclerosis? [DOI]
- 218 The missing Zinc: p53 misfolding and cancer [DOI]
- 219 Novel anti-inflammatory mechanisms ofN-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage [DOI]
- 220 Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu [DOI]
- 221 Zinc Release from Protein Kinase C as the Common Event during Activation by Lipid Second Messenger or Reactive Oxygen [DOI]
- 222 Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors11Abbreviations: Chx, cycloheximide; PARP, poly(ADP-ribose) polymerase; TNFα, tumor necrosis factor alpha; and TPEN: N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine. [DOI]
- 223 Neuronal Zinc Exchange with the Blood Vessel Wall Promotes Cerebral Amyloid Angiopathy in an Animal Model of Alzheimer's Disease [DOI]
- 224 Different redox states of metallothionein/thionein in biological tissue [DOI]
- 225 Zinc prevention and treatment of alcoholic liver disease [DOI]
- 226 Synthesis and Anticancer Properties of Water-Soluble Zinc Ionophores [DOI]
- 227 Zinc at pharmacologic concentrations affects cytokine expression and induces apoptosis of human peripheral blood mononuclear cells [DOI]
- 228 Dose-dependent opposite effect of zinc on apoptosis in mouse thymocytes [DOI]
- 229 Z inc F inger T ranscription F actors in S keletal D evelopment [DOI]
- 230 Chromium(VI) Down-regulates Heavy Metal-induced Metallothionein Gene Transcription by Modifying Transactivation Potential of the Key Transcription Factor, Metal-responsive Transcription Factor 1 [DOI]
- 231 N-acetyl-seryl-aspartyl-lysyl-proline stimulates angiogenesis in vitro and in vivo [DOI]
- 232 Nitric oxide causes apparent release of zinc from presynaptic boutons [DOI]
- 233 Zinc and DNA fragmentation in keratinocyte apoptosis: its inhibitory effect in UVB irradiated cells [DOI]
- 234 Effects of insoluble Zn, Cd, and EDTA on the growth, activities of antioxidant enzymes and uptake of Zn and Cd in Vetiveria zizanioides [DOI]
- 235 Photodynamic effects of isosteric water-soluble phthalocyanines on human nasopharynx KB carcinoma cells [DOI]
- 236 Zinc-Deficient Rat Embryos Have Increased Caspase 3-like Activity and Apoptosis [DOI]
- 237 Peroxidation and externalization of phosphatidylserine associated with release of cytochrome c from mitochondria [DOI]
- 238 The isolated Cys2His2 site in EC metallothionein mediates metal-specific protein folding [DOI]
- 239 Comparison of Zn and Vitamin E for Protection against Hyperoxia-Induced Lung Damage [DOI]
- 240 Tools for metal ion sorting: in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms [DOI]
- 241 Zinc Is Externalized Rather than Released during Synaptic Transmission [DOI]
- 242 Testicular Angiotensin-Converting Enzyme with Different Glycan Modification: Characterization on Glycosylphosphatidylinositol-Anchored Protein Releasing and Dipeptidase Activities [DOI]
- 243 Mechanisms of apoptotic cell death [DOI]
- 244 Errors of homeostasis and deregulated apoptosis [DOI]
- 245 Apoptosis of mouse MS-2 fibrosarcoma cells induced by photodynamic therapy with Zn(II)-phthalocyanine [DOI]
- 246 Rôle du zinc intracellulaire dans la mort cellulaire programmée [DOI]
- 247 The promyelocytic leukemia zinc finger protein down-regulates apoptosis and expression of the proapoptotic BID protein in lymphocytes [DOI]
- 248 Ebselen inhibition of apoptosis by reduction of peroxides [DOI]
- 249 Toxicity identification of metals: Development of toxicity identification fingerprints [DOI]
- 250 Three Distinct Ca2+Influx Pathways Couple Acetylcholine Receptor Activation to Catecholamine Secretion from PC12 Cells [DOI]
- 251 Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple [DOI]
- 252 The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation [DOI]
- 253 The biochemical basis of zinc physiology [DOI]
- 254 Pathological roles of MAPK signaling pathways in human diseases [DOI]
- 255 Genetically encoded fluorescent indicator for intracellular hydrogen peroxide [DOI]
- 256 The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes [DOI]
- 257 Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry [DOI]
- 258 Movement of zinc and its functional significance in the brain [DOI]
- 259 Proteases Universally Recognize Beta Strands In Their Active Sites [DOI]
- 260 Decoding NMDA Receptor Signaling: Identification of Genomic Programs Specifying Neuronal Survival and Death [DOI]
- 261 Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis [DOI]
- 262 Regulation of apoptosis by the redox state of cytochrome c [DOI]
- 263 The challenges of determining metal–protein affinities [DOI]
- 264 Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization [DOI]
- 265 Evolutionary Diversification in Polyamine Biosynthesis [DOI]
- 266 Structure, Properties, and Engineering of the Major Zinc Binding Site on Human Albumin [DOI]
- 267 Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS [DOI]
- 268 Glutaredoxin 2 prevents H2O2-induced cell apoptosis by protecting complex I activity in the mitochondria [DOI]
- 269 Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein [DOI]
- 270 Aven, a Novel Inhibitor of Caspase Activation, Binds Bcl-xL and Apaf-1 [DOI]
- 271 Direct effect of zinc on mitochondrial apoptogenesis in prostate cells [DOI]
- 272 Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide [DOI]
- 273 A New Zinc–protein Coordination Site in Intracellular Metal Trafficking: Solution Structure of the Apo and Zn(II) forms of ZntA(46–118) [DOI]
- 274 Alterations of Zinc Transporter Proteins ZnT‐1, ZnT‐4 and ZnT‐6 in Preclinical Alzheimer's Disease Brain [DOI]
- 275 Release of glutamate and GABA in the hippocampus under zinc deficiency [DOI]
- 276 A Novel RING-Type Ubiquitin Ligase Breast Cancer-Associated Gene 2 Correlates with Outcome in Invasive Breast Cancer [DOI]
- 277 Cytosolic metal handling in plants: determinants for zinc specificity in metal transporters and metallothioneins [DOI]
- 278 Autoubiquitination of BCA2 RING E3 Ligase Regulates Its Own Stability and Affects Cell Migration [DOI]
- 279 Mitochondrial medicine for neurodegenerative diseases [DOI]
- 280 Motexafin Gadolinium and Zinc Induce Oxidative Stress Responses and Apoptosis in B-Cell Lymphoma Lines [DOI]
- 281 Investigation of Lymphocyte Gene Expression for Use as Biomarkers for Zinc Status in Humans [DOI]
- 282 The Molecular Chaperone Hsp90 Regulates Accumulation of DNA Polymerase η at Replication Stalling Sites in UV-Irradiated Cells [DOI]
- 283 Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide [DOI]
- 284 Intracellular zinc increase inhibits p53−/− pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis [DOI]
- 285 Identification of an Allosteric Binding Site for Zn2+on the β2 Adrenergic Receptor [DOI]
- 286 Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats [DOI]
- 287 Imaging Zinc: Old and New Tools [DOI]
- 288 Effects of selenium and zinc on renal oxidative stress and apoptosis induced by fluoride in rats.
- 289 The Role of Apoptosis in Cancer Development and Treatment: Focusing on the Development and Treatment of Hematologic Malignancies [DOI]
- 290 Negative regulation of apoptosis in yeast [DOI]
- 291 Zinc transfer from the embryo-specific metallothionein EC from wheat: a case study [DOI]
- 292 Nitric Oxide Synthase Inhibitor Attenuates Intestinal Damage Induced by Zinc Deficiency in Rats [DOI]
- 293 Relevance of renin expression by real-time PCR in acute myeloid leukemia [DOI]
- 294 Mutation Screening of the ALS2 Gene in Sporadic and Familial Amyotrophic Lateral Sclerosis [DOI]
- 295 Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines [DOI]
- 296 RETRACTED ARTICLE: A Kruüppel-Associated Box-Zinc Finger Protein, NT2, Represses Cell-Type-Specific Promoter Activity of the α2(XI) Collagen Gene [DOI]
- 297 Zinc Status Influences Zinc Transport by Porcine Brain Capillary Endothelial Cells [DOI]
- 298 Inactivation of vascular smooth muscle cells photosensitised by liposome-delivered Zn(II)–phthalocyanine [DOI]
- 299 Differential regulation of Cu, Zn- and Mn-superoxide dismutases by retinoic acid in normal and psoriatic human fibroblasts [DOI]
- 300 MicroRNA-125b is a novel negative regulator of p53 [DOI]
- 301 Free radicals and antioxidants in normal physiological functions and human disease [DOI]
- 302 THE UBIQUITIN SYSTEM [DOI]
- 303 The neurobiology of zinc in health and disease [DOI]
- 304 Control of mitochondrial apoptosis by the Bcl-2 family [DOI]
- 305 Regulation and measurement of oxidative stress in apoptosis [DOI]
- 306 Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease? [DOI]
- 307 Trace Elements in Man and Animals [DOI]
- 308 Close Encounters of the Small Kind: Adverse Effects of Man-Made Materials Interfacing with the Nano-Cosmos of Biological Systems [DOI]
- 309 Cellular Zinc Fluxes and the Regulation of Apoptosis/Gene-Directed Cell Death [DOI]
- 310 Mechanism and Regulation of Cellular Zinc Transport [DOI]
- 311 Oxidative stress generated by dietary Zn-deficiency: studies in rainbow trout (Oncorhynchus mykiss) [DOI]
- 312 Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells [DOI]
- 313 Unconventional Ubiquitin Recognition by the Ubiquitin-Binding Motif within the Y Family DNA Polymerases ι and Rev1 [DOI]
- 314 DNA and RNA from Uninfected Vertebrate Cells Contain Nucleotide Sequences Related to the Putative Transforming Gene of Avian Myelocytomatosis Virus [DOI]
- 315 A Reappraisal of the Role of Zinc in Life and Death Decisions of Cells [DOI]
- 316 Successful treatment of radiation-induced fibrosis using and Mn-SOD: An experimental study [DOI]
- 317 Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity [DOI]
- 318 Zinc as a paracrine effector in pancreatic islet cell death. [DOI]
- 319 Recruitment of TATA-Binding Protein–TAF I Complex SL1 to the Human Ribosomal DNA Promoter Is Mediated by the Carboxy-Terminal Activation Domain of Upstream Binding Factor (UBF) and Is Regulated by UBF Phosphorylation [DOI]
- 320 Stability and apoptotic activity of recombinant human cytochrome c [DOI]
- 321 Cu–Zn super oxide dismutase as a potential antifibrotic drug for hepatitis C related fibrosis [DOI]
- 322 Zinc-Related Magnetic Isotope Effect in the Enzymatic ATP Synthesis: A Medicinal Potential of the Nuclear Spin Selectivity Phenomena [DOI]
- 323 Zinc Transport in the Brain: Routes of Zinc Influx and Efflux in Neurons [DOI]
- 324 N-Acetyl-Seryl-Aspartyl-Lysyl-Proline Inhibits TGF-β–Mediated Plasminogen Activator Inhibitor-1 Expression via Inhibition of Smad Pathway in Human Mesangial Cells [DOI]
- 325 Extracellular Zinc and ATP Restore Chloride Secretion across Cystic Fibrosis Airway Epithelia by Triggering Calcium Entry [DOI]
- 326 Peptidyl-dipeptidase A/angiotensin I-converting enzyme [DOI]
- 327 Zinc Induces Mixed Types of Cell Death, Necrosis, and Apoptosis, in Molt-4 Cells [DOI]
- 328 Uptake pathways and toxicity of Cd and Zn in the earthworm Eisenia fetida [DOI]
- 329 Zinc status affects p53 , gadd45 , and c- fos expression and caspase-3 activity in human bronchial epithelial cells [DOI]
- 330 Mitochondrial DNA–Related Mitochondrial Dysfunction in Neurodegenerative Diseases [DOI]
- 331 Recommended dietary intakes of iron, zinc, and other inorganic nutrients and their chemical form and bioavailability.
- 332 Antioxidant Cu/Zn SOD: Expression in postnatal brain progenitor cells [DOI]
- 333 Phosphate Transfer Enzymes as the Nuclear Spin Selective Nanoreactors
- 334 [Cellular apoptosis: its morphology, biological role and the mechanisms of its development].
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M. A. Orlova, S. A. Roumiantsev, A. P. Orlov · Russian Chemical Bulletin · 2014
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Karolina Wojtunik-Kulesza, Anna Oniszczuk, Monika Waksmundzka-Hajnos · Biomedicine & Pharmacotherapy · 2019
Marina Orlova, Stepan Kalmykov, Tatiana Trofimova · Mini-Reviews in Medicinal Chemistry · 2025
Krishna Prahlad Maremanda, Sabbir Khan, Gopabandhu Jena · Biochemical and Biophysical Research Communications · 2014
A. P. Orlov, M. A. Orlov, T. P. Trofimov · Russian Chemical Bulletin · 2016
Marina A. Orlova, Tatiana P. Trofimova, Ramiz A. Aliev · Journal of Radioanalytical and Nuclear Chemistry · 2016
M. A. Orlova, T. P. Trofimova, M. V. Filimonova · Russian Chemical Bulletin · 2013
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