Skip to content
Research Article Open access CC BY 4.0

Serological Pattern of Hepatitis B Virus Infection and Risk Factors among Infected Individuals in Port Harcourt, Rivers State, Nigeria

Baribefe Banavule Daniel Koate, Teddy Charles Adias, Ebirien-Agana Samuel Bartimaeus, Zacchaeus Awortu Jeremiah

International Blood Research & Reviews · pp. 6–21 · Published 25 Jun 2022

10.9734/ibrr/2022/v13i430182

Abstract

Hepatitis B virus infection is a serious global public health challenge that affects more than two billion people worldwide. This study aimed to evaluate the serological pattern of HBV infection in HBV infected patients in Port Harcourt, Nigeria. The main aim of this study was to evaluate the serological pattern of hepatitis B infection in Port Harcourt, Nigeria. This was a comparative cross sectional study carried out on 260 hepatitis B patients and blood donors attending hepatitis B clinics, and blood banks in Rivers State University Teaching Hospital, Port Harcourt, Military Hospital, Port Harcourt, and University of Port Harcourt Teaching Hospital, Choba. The study involved the use of hepatitis B panel assay, measurement of prevalence of hepatitis B virus infection in Port Harcourt, assessment of hepatitis B serological markers in all subjects, determination of the presence and prevalence of occult HBV among participants. HBV 5-parameter (panel) Rapid Test kit was used to assess HBV serological markers. Standard operation procedure, good laboratory practice, External/Internal Quality Control were used accordingly and Quality Assurance ensued. 84.2% participants were males, 15.8% females aged between 19 and 65 years, Mean ±SD age 30.57±9.70 years, Participants from 20 states, South-South, South-East, and other Geo-political Zones of Nigeria, resident in the cosmopolitan city of Port Harcourt were enrolled. Result obtained showed serological markers among test subjects as 77.3% HBsAg, 43.97% HBsAb, 48.94% HBcAg, 36.17% HBcAb, and 46.81% HBeAg.  Grouping of HBV panel assay result was HBV positive 1 (Occult HBV) 7.8% (n=11), HBV positive 2 73.76% (n=104), HBV positive 3 – (occult HBV post treatment) 14.18% (n=20), HBV positive 4 4.26% (n=6). All five serological markers of HBV in infected patients in PHC are evident in significant proportions indicating real infections at different stages of disease manifestation. Mass screening for HBV infection is recommended for our populace to check spread.

Occult hepatitis serological markers hepatitis panel assay

References (18)

  1. 1 A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) Part II: immunization of adults.
  2. 2 Prevalence of hepatitis B virus infection in Nigeria, 2000-2013: A systematic review and meta-analysis [DOI]
  3. 3 Hepatitis B Virus Blood Screening: Need for Reappraisal of Blood Safety Measures? [DOI]
  4. 4 Role of viral factors in the natural course and therapy of chronic hepatitis B [DOI]
  5. 5 Prevalence of Hepatitis B virus markers in surgeons in Lagos, Nigeria [DOI]
  6. 6 Seroprevalence of hepatitis B virus serological markers among pregnant Nigerian women [DOI]
  7. 7 Studies on Prevalence and Risk Factors for Hepatitis B Surface Antigen among Secondary School Students in North-central, Nigeria
  8. 8 Serum Hepatitis C virus and hepatitis B surface antigenaemia in Nigerian patients with acute Icteric hepatitis [DOI]
  9. 9 Prevalence of hepatitis B virus surface antigen among healthy asymptomatic students in a Nigerian University [DOI]
  10. 10 Markers of hepatitis B virus infection in a subset of young people in central Nigeria [DOI]
  11. 11 Seroprevalence of hepatitis B virus in a tertiary institution in North Western Nigeria [DOI]
  12. 12 The prevalence of hepatitis B surface antigen (HBsAg) among prospective blood donors and patients in Port Harcourt, Nigeria.
  13. 13 Evaluation of Some Immunological and Haematological Indices of Hepatitis B Infected Subjects in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria [DOI]
  14. 14 Hepatitis B Virus Carriage among Students of a Nigerian Tertiary Institution: A Cohort of Eligible Blood Donors [DOI]
  15. 15 Screening for Hepatitis B Virus Infection in Nonpregnant Adolescents and Adults.
  16. 16 Seroprevalence of hepatitis b surface antigen (HBsAg) among the medicalstudents of Usmanu Danfodiyo University, Sokoto, Sokoto State, Nigeria
  17. 17 European Journal of Experimental Biology [DOI]
  18. 18 International Journal of Medicine and Medical Sciences [DOI]

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

41

Page views

0

PDF downloads

6

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.