Seroprevalence of Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) and Syphilis among Voluntary Blood Donors in Rural Southwestern Uganda: A Retrospective Study
Richard Onyuthi Apecu, Edgar M. Mulogo, Fred Bagenda, Andrew Byamungu, Yap Boum II, Joel Bazira, Frederic Byarugaba
International Journal of TROPICAL DISEASE & Health · pp. 1–13 · Published 24 Nov 2017
10.9734/IJTDH/2017/34605Abstract
Despite the improvement with blood screening, transfusion transmissible infectious (TTIs) agents such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis are still among some of the challenges in the blood safety for the recipient in Uganda. The aim of this study was to determine the prevalence of the four TTIs among the voluntary blood donors in southwestern Uganda. A retrospective study was conducted using one year data (January 2014 to December 2014) from a regional blood bank in southwestern Uganda. Routine screening by the blood bank included anti HIV, hepatitis B surface antigen, anti-hepatitis C using the Abbott ARCHITECT i2000 SR analyzer. Both Rapid Plasma Reagin (RPR) test and Treponema Pallidun Haeagglutination (TPHA) tests were used for detection of syphilitic infection. 5.67% of blood donors were positive for any of the screening tests and 0.34% had multiple infections. The overall seroprevalence was 1.03%, 1.87%, 2.22%, and 0.54% for HIV, HBV, HCV and syphilis respectively. The most common dual combinations were HBV-HCV 51.8 %, HIV-HCV 22.7% and HIV-HBV 10.0%. Triple infection with HIV-HBV-HCV was 3.7% and HIV- HBV-Syphilis was 1.3%. There were no quadruple infections detected in this study. There was statistically significant increase of HIV seropositivity among the age group of donors above 47 years (p=0.001). A substantial prevalence of TTIs was found among the blood donors in southwestern Uganda.
References (30)
- 1 The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide [DOI]
- 2 Evolving epidemiology of hepatitis C virus [DOI]
- 3 Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years [DOI]
- 4 Hepatitis B virus/hepatitis C virus coinfection: Epidemiology, clinical features, viral interactions and treatment [DOI]
- 5 Voluntary HIV counselling and testing among men in rural western Uganda: Implications for HIV prevention [DOI]
- 6 Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses and syphilis infections among blood donors at the Muhimbili National Hospital in Dar Es Salaam, Tanzania [DOI]
- 7 Sero-epidemiology of transfusion-transmissible infectious diseases among blood donors in Osogbo, south-west Nigeria. [DOI]
- 8 Seroprevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana [DOI]
- 9 The risk of transfusion‐transmitted infections in sub‐Saharan Africa [DOI]
- 10 HCV syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin’s lymphoma, and cancer [DOI]
- 11 Coinfection with Hepatitis C Virus and Human Immunodeficiency Virus: Virological, Immunological, and Clinical Outcomes [DOI]
- 12 Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Dual Infection [DOI]
- 13 The challenges of meeting the blood transfusion requirements in Sub-Saharan Africa: the need for the development of alternatives to allogenic blood [DOI]
- 14 Reductions in risk behaviour provide the most consistent explanation for declining HIV-1 prevalence in Uganda [DOI]
- 15 Prevalence of Blood-Borne Infectious Diseases in Blood Donors in Ghana [DOI]
- 16 Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses and syphilis among blood donors in Koudougou (Burkina Faso) in 2009. [DOI]
- 17 Seroprevalence of transfusion-transmissible infections and evaluation of the pre-donation screening performance at the Provincial Hospital of Tete, Mozambique [DOI]
- 18 Transfusion transmitted infections – A retrospective analysis from the National Blood Transfusion Service in Eritrea [DOI]
- 19 Prevalence of hepatitis B and C viral co-infections among HIV-1 infected individuals in Nairobi, Kenya [DOI]
- 20 Prevalence of Transfusion Transmitted Infections in Voluntary and Replacement Donors [DOI]
- 21 Seroprevalence of transfusion transmissible infections among voluntary blood donors at a tertiary care teaching hospital in rural area of India [DOI]
- 22 Prevalence of human immunodeficiency virus, syphilis, hepatitis B and C in blood donations in Namibia [DOI]
- 23 HIV, HBV, HCV and T. palliduminfections among blood donors and Transfusion-related complications among recipients at the Laquintinie hospital in Douala, Cameroon [DOI]
- 24 Relationship between infectious diseases and human blood type [DOI]
- 25 Treatment of HBV/HCV coinfection [DOI]
- 26 Seroprevalence of transfusion transmissible infections among blood donors at the blood bank of a Medical College of Kolkata [DOI]
- 27 Maternal syphilis and vertical perinatal transmission of human immunodeficiency virus type‐1 infection [DOI]
- 28 Prevalence of Antibodies to Syphilis among Blood Donors in Accra, Ghana [DOI]
- 29 Seroprevalence of hepatitis C virus in the general population of northwest Tanzania. [DOI]
- 30 THE PREVALENCE OF HEPATITIS B SURFACE ANTIGENAEMIA IN PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS (HIV)INFECTION IN GOMBE, NIGERIA
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