Simultaneous Determination of Piracetam and Citicoline in Combination Drug Products by Rp-Hplc Method
Meka. Srinivasa Rao, K. Rambabu
Journal of Pharmaceutical Research International · pp. 171–185 · Published 2 Aug 2021
10.9734/jpri/2021/v33i39B32193Abstract
In this paper a simple, accurate and precise RP-HPLC method for the simultaneous. Estimation of piracetam and citicoline in synthetic mixtures has been developed and validated. Separation of drugs was carried out using buffer and Acetonitryle with proportion of 60:40 %v/v as mobile phase at 5 min. run time and 265nm. The Rt value for piracetam and citicoline was found to be 3.158 and 5.196 min respectively. The developed method has been validated for linearity, accuracy and precision, LOD, LOQ, and system suitability according to ICH guidelines. The low values of LOD and LOQ illustrate that the developed method was sensitive, accurate, and precise as it can detected and quantify with very low concentration. The low % RSD values below 2 indicate that the method is precise. The above validation studies revealed the method is specific, rapid, reliable, and reproducible. The high recovery and low relative standard deviation confirm the suitability of the method for routine determination of piracetam and citicoline in combined dose products.
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Zheng Zhou, Mingxuan Liu, Haoyu You · Advanced Functional Materials · 2025
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