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Research Article Open access CC BY 4.0

Spectrophotometric determination of Ciprofloxacin Hydrochloride, Moxifloxacin Hydrochloride and Roxithromycin Hydrochloride in Pure Form

M. S. Mohammed, H. H. El-Feky, T. Y. Mohammed, S. A. Shama

Asian Journal of Chemical Sciences · pp. 45–53 · Published 12 Jul 2022

10.9734/ajocs/2022/v12i119139

Abstract

A straightforward, sensitive, and quick spectrophotometric approach was created and validated for the detection of Ciprofloxacin hydrochloride, Moxifloxacin hydrochloride, and Roxithromycin hydrochloride in pure form. These techniques were based upon the fact that these antibiotics produced dark yellow ion pairs when combined with bromophenol blue. The binary complex in universal buffer solution of the optimum pH values was demonstrated at absorption maxima at 633 nm, 632 nm, and 633 nm for the three drugs, respectively, with bromophenol blue. Various parameters, such as the effect of time and the effect of reagent concentration, were optimized. Beer’s law plots were obeyed in the concentration ranges 2– 8 µg ml-1, 1– 4 µg ml-1, and 1– 6 µg ml-1, for the three drugs, respectively, with bromophenol blue. The detection limits were found to be 1.65, 0.83 and 0.79 μg mL-1, respectively, for Ciprofloxacin hydrochloride, Moxifloxacin hydrochloride, and Roxithromycin hydrochloride with bromophenol blue. The correlation coefficient value suggests that all three systems are linearly consistent.

Ciprofloxacin hydrochloride moxifloxacin hydrochloride and roxithromycin hydrochloride bromophenol blue Ion pair complex

References (26)

  1. 1 Antibiotics in the aquatic environment – A review – Part I [DOI]
  2. 2 Colorimetric Sensor Arrays for Volatile Organic Compounds [DOI]
  3. 3 Fungal decolouration and degradation of azo dyes: A review [DOI]
  4. 4 Colorimetric Sensor Array for Determination and Identification of Toxic Industrial Chemicals [DOI]
  5. 5 Impact of roxithromycin on waste activated sludge anaerobic digestion: Methane production, carbon transformation and antibiotic resistance genes [DOI]
  6. 6 Quinolone Antimicrobial Agents [DOI]
  7. 7 Pharmacokinetics of a Once-Daily Oral Dose of Moxifloxacin (Bay 12-8039), a New Enantiomerically Pure 8-Methoxy Quinolone [DOI]
  8. 8 RNAcompete methodology and application to determine sequence preferences of unconventional RNA-binding proteins [DOI]
  9. 9 Electrochemical decolorization of methyl orange powered by bioelectricity from single-chamber microbial fuel cells [DOI]
  10. 10 Immobilization of laccase on Sepharose-linked antibody support for decolourization of phenol red [DOI]
  11. 11 A Fiber Optic Ammonia Sensor Using a Universal pH Indicator [DOI]
  12. 12 Calcium Signals Are Affected by Ciprofloxacin as a Consequence of Reduction of Mitochondrial DNA Content in Jurkat Cells [DOI]
  13. 13 Roxithromycin: a pharmacokinetic review of a macrolide [DOI]
  14. 14 Spectrophotometric Determination of Gemifloxacin Mesylate, Moxifloxacin Hydrochloride, and Enrofloxacin in Pharmaceutical Formulations Using Acid Dyes [DOI]
  15. 15 Determination of acidity constants of bromophenol blue and phenol red indicators by solution scanometric method and comparison with spectrophotometric results [DOI]
  16. 16 Anxiogenic potential of ciprofloxacin and norfloxacin in rats.
  17. 17 An efficient decolorization of methyl orange dye by laccase from Marasmiellus palmivorus immobilized on chitosan-coated magnetic particles [DOI]
  18. 18 The effect of ciprofloxacin on sperm DNA damage, fertility potential and early embryonic development in NMRI mice.
  19. 19 Preferential solvation bromophenol blue in water-alcohol binary mixture [DOI]
  20. 20 Substitution reactions of benzethonium chloride with ion associates of bromocresol green – quinine and bromophenol blue – quinine in dichloromethane [DOI]
  21. 21 Colorimetric Evaluation of Mahi-Mahi and Tuna for Biogenic Amines [DOI]
  22. 22 Does Olive Oil Attenuate Ciprofloxacin-Induced Renal Cortical Toxicity? Light and Electron Microscopic Study [DOI]
  23. 23 Ciprofloxacin induced hormonal changes in the thyroid gland of rats and Anti-oxidant vitamin A, C and E as rescue agents [DOI]
  24. 24 Synthesis, Characterization, Spectrofluorometric and Antibacterial Activity Studies of Moxifloxacin- Zirconium Complex [DOI]
  25. 25 Yaşlı Kadınlarda Üreme Sağlığı
  26. 26 Erratum to: Roxithromycin: an update of its antimicrobial activity, pharmacokinetic properties and therapeutic use [DOI]

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