Structure Based Drug Discovery, Docking, Modelling, Synthesis and Anticancer Screening of Some Novel Quinoline Derivatives
Bharat Shivaji Honde, Kunkulol Rahul Rajendra
Journal of Pharmaceutical Research International · pp. 341–353 · Published 28 Dec 2021
10.9734/jpri/2021/v33i62A35384Abstract
A new series of (2-(substituted-phenyl) quinoline-4-yl) (3-(substituted phenyl)-5-phenyl-1H-pyrazol-1-yl) methanone derivatives was carried out docking modelling and synthesized. Purity was checked by TLC and chemical structures of synthesized compounds were elucidated by their IR, 1HNMR, MS analysis data. The synthesized compounds were screened for anticancer activity by using cell line MCF-7 (Human breast cancer cell line) correlate with docking modelling.
Cited by 1
Samuel Nzube Nwosu · Journal of Advances in Medical and Pharmaceutical Sciences · 2024
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