Skip to content
Research Article Open access CC BY 4.0

Study of Genetic Drifts in Some Fat Mass and Obesity Associated Gene Variatiants in Type 2 Diabetics in Some Ethinic Groups Residing in Delta State, Nigeria

H. Osere, H. Brown, K. N. Elechi-Amadi

Asian Journal of Research in Medical and Pharmaceutical Sciences · pp. 21–30 · Published 16 Jan 2024

10.9734/ajrimps/2024/v13i1244

Abstract

Aim: Detailing and distribution of some predominant FTO genes among subjects with diabetes mellitus selected from Igbo, Ika, Ijaw and Isoko tribes of Delta state, Nigeria. Study Design: Case-control, observational study. Place and Duration of Study: Federal Medical Center, Asaba, Delta State and Safety Molecular Pathology Laboratory Enugu, Nigeria, between March 2020 and Febuary 2022. Methodology:100 subjects (20 diabetic and 5 non diabetic from each of the four tribes; age range; 28-74 years) Venous blood was collected for the assay of FBS, Hb1ac and molecular assay of four variants of FTO (Fat Mass and Obesity Associated) gene. Results obtained were statistically analysed. Result: The genotypes identified in the subjects were AA, GA, GG, AC, CC, TT, and AT.  AA (Ijaw 17, Urhobo 18, Ika 18, Igbo 19) and GG (Ijaw 17, Urhobo 18, Ika 19, Igbo 18) had highest level of occurrence in all tribes. Recombinant genotype and recessive allele had higher number of subjects as compared to the originating genotypes. Hardy- Weinberg statistics demonstrated significant genetic deviations in rs2388405(AA -0.12 x2 =0.0002, GA 0.12 x2=0.002) rs201041270(GG-0.12 x2 =0.0002, GA 2.12 x2=0.002), and rs8050136 (CC -0.34 x2 =0.001, AC 2.32, x2=0.05) proving a chance of finding new SNP in the studied population with a probability of 2.25 as seen in the odd ratio of T allele in Igbo tribe. Conclusion: Statistically significant genetic drifts exist in the studied population.

Obesity diabetes ethinic groups gene genetic drifts fat mass

References (15)

  1. 1 The bigger picture of FTO—the first GWAS-identified obesity gene [DOI]
  2. 2 Genetics of Type 2 Diabetes—Pitfalls and Possibilities [DOI]
  3. 3 DNA methylation and its role in the pathogenesis of diabetes [DOI]
  4. 4 Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk [DOI]
  5. 5 Hardy-Weinberg Equilibrium in the Large Scale Genomic Sequencing Era [DOI]
  6. 6 Association of FTO gene variant (rs8050136) with type 2 diabetes and markers of obesity, glycaemic control and inflammation [DOI]
  7. 7 FTO Gene Associates and Interacts with Obesity Risk, Physical Activity, Energy Intake, and Time Spent Sitting: Pilot Study in a Nigerian Population [DOI]
  8. 8 Evidence for the association between FTO gene variants and vitamin B12 concentrations in an Asian Indian population [DOI]
  9. 9 Recombination affects allele-specific expression of deleterious variants in human populations [DOI]
  10. 10 Frequency distribution and association of Fat-mass and obesity (FTO) gene SNP rs-9939609 variant with Diabetes Mellitus Type-II population of Hyderabad, Sindh, Pakistan [DOI]
  11. 11 Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon [DOI]
  12. 12 Estimation of Glycated Haemoglobin by Nephelometry, Ion Exchange Resin and High Performance Liquid Chromatography: A Cross-sectional Study [DOI]
  13. 13 The effects of fat mass and obesity-associated gene variants on the body mass index among ethnic groups and in children and adults [DOI]
  14. 14 Correlation of glycated haemoglobin with fasting and post prandial blood glucose in Type 2 diabetes [DOI]
  15. 15 Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy [DOI]

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

32

Page views

0

PDF downloads

9

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.