Study of the Effectiveness of Chitosan Encapsulated Iron Oxide Nanoparticles
M. Hebzi Emalda Rani, S. Mary Helen
Journal of Pharmaceutical Research International · pp. 208–213 · Published 28 Dec 2021
10.9734/jpri/2021/v33i61B35507Abstract
The magnetic iron oxide nanoparticles have been synthesized by using co-precipitation approach. Chitosan coated nanoparticles compare the effect of surface coating on the stability and toxicity of nanoparticles. Invitro cytotoxicity of the nanoparticles are evaluated by three-(four-5) dimethyl thiazole-2-yl and -two,5, diphenyl thiazoniam bromide (MTT assay) along with glide cytometry examine for cell viability. Does dependent reduction was observed in SKMEL cancer cells administered with different concentration of the sample. I50 value obtained for the Iron nanoparticle is 217.75µg/Ml. The fluorescence primarily based real time opposite transcription PCR(RT-PCR) is widely used for the quantification of constant state mRNA ranges and is a crucial device for primary research molecular medicine and biotechnology. FTIR amino companies were acted as capping sites for the iron nanoparticles stabilization. In antibacterial studies Gentamycin 80mcg showed the higher activity of Iron nanoparticles.
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