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Research Article Open access CC BY 4.0

Super Porous Hydrogels: A Review

P. V. Kamala Kumari, M. Sharmila, Y. Srinivasa Rao

Journal of Pharmaceutical Research International · pp. 153–165 · Published 6 Aug 2020

10.9734/jpri/2020/v32i1330595

Abstract

Super porous hydrogels (SPHs) basically developed  initially create as a novel drug delivery system to absorb and continue to hold the drugs in the gastric medium which allows absorption  in stomach and upper part of the gastrointestinal tract. These systems get swollen in the stomach instantly and in the harsh stomach environment they maintain their integrity, while the pharmaceutical active ingredient is being released. Instant and fast swelling property of hydrogel  is based on water absorption through open porous structure by capillary force. SPHs have the poor mechanical strength which has got over by developing the second-generation SPH composites (SPHCs) and the third-generation SPH hybrids (SPHHs).  The present review has been focused on the preparation, characterization and application of SPHs.

Super porous hydrogels gastric retention absorption window second and third generation SPH.

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