The Cell Based Model of in-vivo Coagulation: A Work in Progress
Biswaprakash Patri, Anubhav Abinash Sahu, Souravi Pal, Sukumar Chakravarty
International Blood Research & Reviews · pp. 1–10 · Published 15 Jun 2016
10.9734/IBRR/2016/26906Abstract
The goal of this article is to review the evolution of theories of coagulation and their proposed models to serve as a tool. When reviewing the research and practice literature that was published in the context of these theories over time, including the critical contribution of cells, we have observed a model based on work of many workers, in which Hemostasis is regulated by various properties of cell surface, which occurs in vivo. The coagulation occurs not as a cascade/waterfall, but occurs in 4 overlapping steps-(i) Initiation, (ii) Amplification, (iii) Propagation, (iv) Termination. Cell Based model has given an insight into the pathophysiological mechanism of certain coagulation disorders which were till now ill understood.
References (23)
- 1 An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier [DOI]
- 2 Circulating microparticles: pathophysiology and clinical implications [DOI]
- 3 Inflammation, endothelium, and coagulation in sepsis [DOI]
- 4 What is all that thrombin for? [DOI]
- 5 The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. [DOI]
- 6 Remodeling the Blood Coagulation Cascade [DOI]
- 7 A Cell-Based Model of Thrombin Generation [DOI]
- 8 The cell‐based model of coagulation [DOI]
- 9 Activation of human factor V by factor Xa and thrombin [DOI]
- 10 Platelet microparticles and vascular cells interactions: A checkpoint between the haemostatic and thrombotic responses [DOI]
- 11 Phosphatidylethanolamine augments factor VIIa-tissue factor activity: enhancement of sensitivity to phosphatidylserine [DOI]
- 12 Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. [DOI]
- 13 Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo. [DOI]
- 14 Comparative interactions of factor IX and factor IXa with human platelets [DOI]
- 15 Coagulation Factor IXa Binding to Activated Platelets and Platelet-Derived Microparticles: A Flow Cytometric Study [DOI]
- 16 Antithrombotic and prothrombotic activities of the vascular endothelium [DOI]
- 17 Structural and Functional Characterization of Platelet Receptor-mediated Factor VIII Binding [DOI]
- 18 O novo modelo da cascata de coagulação baseado nas superfícies celulares e suas implicações [DOI]
- 19 Binding of coagulation factor XI to washed human platelets [DOI]
- 20 Factor XI Binding to Activated Platelets Is Mediated by Residues R250, K255, F260, and Q263 within the Apple 3 Domain [DOI]
- 21 Tissue factor; from Morawitz to microparticles.
- 22 Thrombin facilitates primary platelet adhesion onto vascular surfaces in the absence of plasma adhesive proteins: studies under flow conditions.
- 23 Recombinant fragment of von Willebrand factor AR545C inhibits platelet binding to thrombin and platelet adhesion to thrombin‐treated endothelial cells [DOI]
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