The Effect of Biomays on Lipoprotein Receptors in the Dynamics of Development of Experimental Atherosclerosis

Abstract

In Asia, wheat sprouts (OP) has long been used as a traditional herbal medicine. Polikozanol, vitamins and polyunsaturated fatty acids - have different biological activity: anti-inflammatory, antioxidant, antidiabetic and lipid-lowering. Aim: Investigate the effect of biomays on lipoprotein receptors in the dynamics of development of experimental atherosclerosis Materials and Methods of Research: We decided to study the effect of the domestic drug "Biomays" in the treatment of experimental atherosclerosis. The study involved 5 groups of rabbits: 1st - intact (normal), 2nd - rabbits with hypercholesterolemia, 3rd - treatment with ultrax, 4th - treatment with biomice, 5th - received mixed treatment. Investigated the concentration of LOX- 1 and LDLR on the 60th, 70th, 80th and 90th days of hypercholesterolemia. Results: Thus, the combination of Biomays and Ultrox has the most beneficial effect on LOX- 1 and rLDL parameters than monotherapy. In animals treated with both statins and Biomays, plasma LOX - 1 ligand levels were maintained at lower levels than untreated rabbits. Conclusion:  We have found that the use of a statin in combination with dietary supplements "Biomays" (Maysara) has a synergistic effect improves the expression of r LDL and LDL uptake.