The Hsp90 Chaperone Machinery: An Important Hub in Protein Interaction Networks

References (227)

1. 1 HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor [DOI]
2. 2 The 90-kDa Molecular Chaperone Family [DOI]
3. 3 Navigating the Chaperone Network: An Integrative Map of Physical and Genetic Interactions Mediated by the Hsp90 Chaperone [DOI]
4. 4 The mystery of nonclassical protein secretion [DOI]
5. 5 An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function [DOI]
6. 6 Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin [DOI]
7. 7 The hsp90-related Protein TRAP1 Is a Mitochondrial Protein with Distinct Functional Properties [DOI]
8. 8 Heat shock protein expression independently predicts clinical outcome in prostate cancer.
9. 9 Phylogenetic analysis of the 90 kD heat shock family of protein sequences and an examination of the relationship among animals, plants, and fungi species. [DOI]
10. 10 Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones [DOI]
11. 11 Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.
12. 12 Broad action of Hsp90 as a host chaperone required for viral replication [DOI]
13. 13 Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents [DOI]
14. 14 Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy [DOI]
15. 15 Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle [DOI]
16. 16 Nitration of Hsp90 induces cell death [DOI]
17. 17 Identification of Citrullinated Hsp90 Isoforms as Novel Autoantigens in Rheumatoid Arthritis–Associated Interstitial Lung Disease [DOI]
18. 18 Curcumin and its analogues: a potential natural compound against HIV infection and AIDS [DOI]
19. 19 Characterization of the mammalian miRNA turnover landscape [DOI]
20. 20 A Phase II Open-Label Study of Ganetespib, a Novel Heat Shock Protein 90 Inhibitor for Patients With Metastatic Breast Cancer [DOI]
21. 21 Molecular Interaction Network of the Hsp90 Chaperone System [DOI]
22. 22 Heat shock proteins HSP27, HSP60, HSP70, and HSP90 [DOI]
23. 23 The Carboxy-Terminal Region of Mammalian HSP90 Is Required for Its Dimerization and Function In Vivo [DOI]
24. 24 Modulation of Chaperone Function and Cochaperone Interaction by Novobiocin in the C-terminal Domain of Hsp90 [DOI]
25. 25 (−)-Epigallocatechin-3-gallate Is a Novel Hsp90 Inhibitor [DOI]
26. 26 Hsp 90α and Hsp 90β Genes Are Present in the Zebrafish and Are Differentially Regulated in Developing Embryos [DOI]
27. 27 Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore [DOI]
28. 28 Protein Kinase A-dependent Translocation of Hsp90α Impairs Endothelial Nitric-oxide Synthase Activity in High Glucose and Diabetes [DOI]
29. 29 Heat Shock Protein 90 Positively Regulates Chikungunya Virus Replication by Stabilizing Viral Non-Structural Protein nsP2 during Infection [DOI]
30. 30 Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT [DOI]
31. 31 The activity of hsp90α promoter is regulated by NF-κB transcription factors [DOI]
32. 32 Expression of potential molecular markers in prostate cancer: Correlation with clinicopathological outcomes in patients undergoing radical prostatectomy [DOI]
33. 33 BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance [DOI]
34. 34 The heat shock protein 90 inhibitor 17‐AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9 [DOI]
35. 35 Expression of heat‐shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries [DOI]
36. 36 Functions of the Hsp90 chaperone system: lifting client proteins to new heights.
37. 37 Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses [DOI]
38. 38 A Phase 1, Dose-Escalation, Pharmacokinetic and Pharmacodynamic Study of BIIB021 Administered Orally in Patients with Advanced Solid Tumors [DOI]
39. 39 MicroRNAs mediated targeting on the Yin-yang dynamics of DNA methylation in disease and development [DOI]
40. 40 HSP90 inhibitor AUY922 induces cell death by disruption of the Bcr-Abl, Jak2 and HSP90 signaling network complex in leukemia cells [DOI]
41. 41 Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex [DOI]
42. 42 Oligomeric forms of the 90-kDa heat shock protein [DOI]
43. 43 Hsp90 reaches new heights [DOI]
44. 44 Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis [DOI]
45. 45 Impairment of Mineralocorticoid Receptor (MR)-dependent Biological Response by Oxidative Stress and Aging [DOI]
46. 46 Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma [DOI]
47. 47 Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer [DOI]
48. 48 Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase [DOI]
49. 49 Theiler’s murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin [DOI]
50. 50 Steroid Binding Activity Is Retained in a 16-kDa Fragment of the Steroid Binding Domain of Rat Glucocorticoid Receptors [DOI]
51. 51 Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones* [DOI]
52. 52 Heat shock factors: integrators of cell stress, development and lifespan [DOI]
53. 53 A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors [DOI]
54. 54 Roles of the heat shock transcription factors in regulation of the heat shock response and beyond [DOI]
55. 55 Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin [DOI]
56. 56 Hsp90 inhibitors as novel cancer chemotherapeutic agents [DOI]
57. 57 The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N‐terminal domains [DOI]
58. 58 Structural Analysis of E. coli hsp90 Reveals Dramatic Nucleotide-Dependent Conformational Rearrangements [DOI]
59. 59 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer [DOI]
60. 60 Structure and in vivo function of Hsp90 [DOI]
61. 61 Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket [DOI]
62. 62 Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3 [DOI]
63. 63 Post-translational modifications of Hsp90 and their contributions to chaperone regulation [DOI]
64. 64 An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine [DOI]
65. 65 The role of Hsp90 in protein complex assembly [DOI]
66. 66 Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity [DOI]
67. 67 Convergence of Heat Shock Protein 90 with Ubiquitin in Filamentous α-Synuclein Inclusions of α-Synucleinopathies [DOI]
68. 68 Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia [DOI]
69. 69 STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90α and β in multiple myeloma cells, which critically contribute to tumor-cell survival [DOI]
70. 70 Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits [DOI]
71. 71 Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors [DOI]
72. 72 Inhibition of heat-shock protein 90 reduces Ebola virus replication [DOI]
73. 73 Heat Shock Protein 90B1 Plays an Oncogenic Role and is a Target of microRNA-223 in Human Osteosarcoma [DOI]
74. 74 The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition [DOI]
75. 75 Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World [DOI]
76. 76 A Critical Role for HSP90 in Cancer Cell Invasion Involves Interaction with the Extracellular Domain of HER-2 [DOI]
77. 77 Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses [DOI]
78. 78 Signal Transducer and Activator of Transcription-1 and Heat Shock Factor-1 Interact and Activate the Transcription of the Hsp-70 and Hsp-90β Gene Promoters [DOI]
79. 79 Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo [DOI]
80. 80 Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice [DOI]
81. 81 Analysis of the Tau-Associated Proteome Reveals That Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation [DOI]
82. 82 Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1α and STAT-3 [DOI]
83. 83 Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies [DOI]
84. 84 HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasion [DOI]
85. 85 A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancer [DOI]
86. 86 Sensitizing tumor cells to radiation by targeting the heat shock response [DOI]
87. 87 MicroRNA-27b plays a role in pulmonary arterial hypertension by modulating peroxisome proliferator-activated receptor γ dependent Hsp90-eNOS signaling and nitric oxide production [DOI]
88. 88 Phase I Trial of the HSP90 Inhibitor PF-04929113 (SNX5422) in Adult Patients With Recurrent, Refractory Hematologic Malignancies [DOI]
89. 89 EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells [DOI]
90. 90 Active Participation of Cellular Chaperone Hsp90 in Regulating the Function of Rotavirus Nonstructural Protein 3 (NSP3) [DOI]
91. 91 Hsp90: from structure to phenotype [DOI]
92. 92 A block in the road to fertility: autoantibodies to heat-shock protein 90-β in human ovarian autoimmunity [DOI]
93. 93 Natural killer cells play a key role in the antitumor immunity generated by chaperone‐rich cell lysate vaccination [DOI]
94. 94 Identification and purification from the plasma of Type�1 diabetic subjects of a proteolytically active Grp94 [DOI]
95. 95 The expanding proteome of the molecular chaperone HSP90 [DOI]
96. 96 Curcumin derivative C817 inhibits proliferation of imatinib-resistant chronic myeloid leukemia cells with wild-type or mutant Bcr-Abl in vitro [DOI]
97. 97 Binding partners for curcumin in human schwannoma cells: Biologic Implications [DOI]
98. 98 Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia [DOI]
99. 99 Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxygeldanamycin promotes TRAIL-induced apoptosis in breast tumor cells [DOI]
100. 100 SNX-25a, a novel Hsp90 inhibitor, inhibited human cancer growth more potently than 17-AAG [DOI]
101. 101 A new puffing pattern induced by temperature shock and DNP in drosophila [DOI]
102. 102 Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway [DOI]
103. 103 Heat shock proteins in cancer: chaperones of tumorigenesis [DOI]
104. 104 Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition [DOI]
105. 105 Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1 [DOI]
106. 106 Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations [DOI]
107. 107 The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone [DOI]
108. 108 A New First Step in Activation of Steroid Receptors [DOI]
109. 109 Selective release from cultured mammalian cells of heat‐shock (stress) proteins that resemble glia‐axon transfer proteins [DOI]
110. 110 Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin [DOI]
111. 111 Rational design of shepherdin, a novel anticancer agent [DOI]
112. 112 Cross-Presentation of Glycoprotein 96–Associated Antigens on Major Histocompatibility Complex Class I Molecules Requires Receptor-Mediated Endocytosis [DOI]
113. 113 Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms [DOI]
114. 114 Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis [DOI]
115. 115 Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions [DOI]
116. 116 New insights into the mechanism of heat shock response activation [DOI]
117. 117 Large‐scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography [DOI]
118. 118 Inhibition of Hsp90 Down-regulates Mutant Epidermal Growth Factor Receptor (EGFR) Expression and Sensitizes EGFR Mutant Tumors to Paclitaxel [DOI]
119. 119 Regulation of the Dynamics of hsp90 Action on the Glucocorticoid Receptor by Acetylation/Deacetylation of the Chaperone [DOI]
120. 120 A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas [DOI]
121. 121 Hsp90 inhibitors reduce influenza virus replication in cell culture [DOI]
122. 122 Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis [DOI]
123. 123 HSP90 as a marker of progression in melanoma [DOI]
124. 124 Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation [DOI]
125. 125 Possible Role for Serine/Threonine Phosphorylation in the Regulation of the Heteroprotein Complex between the hsp90 Stress Protein and the pp60v-src Tyrosine Kinase [DOI]
126. 126 Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors [DOI]
127. 127 The Hsp90 Cochaperone p23 Is the Limiting Component of the Multiprotein Hsp90/Hsp70-based Chaperone System in Vivo Where It Acts to Stabilize the Client Protein·Hsp90 Complex [DOI]
128. 128 Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90 [DOI]
129. 129 Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT [DOI]
130. 130 Bcr-Abl-Independent Imatinib-Resistant K562 Cells Show Aberrant Protein Acetylation and Increased Sensitivity to Histone Deacetylase Inhibitors [DOI]
131. 131 Mini-review: Foldosome regulation of androgen receptor action in prostate cancer [DOI]
132. 132 Heat Shock Protein 90 Inhibitor BIIB021 (CNF2024) Depletes NF-κB and Sensitizes Hodgkin's Lymphoma Cells for Natural Killer Cell–Mediated Cytotoxicity [DOI]
133. 133 Molecular chaperones in mammary cancer growth and breast tumor therapy [DOI]
134. 134 Allosteric Regulation of the Hsp90 Dynamics and Stability by Client Recruiter Cochaperones: Protein Structure Network Modeling [DOI]
135. 135 Heat-induced Chaperone Activity of HSP90 [DOI]
136. 136 Dihydroquinone Ansamycins: Toward Resolving the Conflict between Low in Vitro Affinity and High Cellular Potency of Geldanamycin Derivatives [DOI]
137. 137 BAG3, a Host Cochaperone, Facilitates Varicella-Zoster Virus Replication [DOI]
138. 138 Evolutionary Origins of Hsp90 Chaperones and a Deep Paralogy in their Bacterial Ancestors [DOI]
139. 139 RETRACTED ARTICLE: Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin [DOI]
140. 140 Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis [DOI]
141. 141 5-Episinuleptolide Acetate, a Norcembranoidal Diterpene from the Formosan Soft Coral Sinularia sp., Induces Leukemia Cell Apoptosis through Hsp90 Inhibition [DOI]
142. 142 Serum Antibodies to Porphyromonas gingivalis Chaperone HtpG Predict Health in Periodontitis Susceptible Patients [DOI]
143. 143 Combination of Bortezomib and Mitotic Inhibitors Down-Modulate Bcr-Abl and Efficiently Eliminates Tyrosine-Kinase Inhibitor Sensitive and Resistant Bcr-Abl-Positive Leukemic Cells [DOI]
144. 144 Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors [DOI]
145. 145 The Effects of Heat Shock Protein 90 Inhibitors on Apoptosis and Viral Replication in Primary Effusion Lymphoma Cells [DOI]
146. 146 Trends of Chemistry: Chemistry in America, 1876-1976. Historical Indicators . Arnold Thackray, Jeffrey L. Sturchio, P. Thomas Carroll, and Robert Bud. Reidel, Boston, 1985 (distributor, Kluwer, Hingham, Mass.). xxiv, 564 pp., illus. $79.50. Chemists and Chemistry. [DOI]
147. 147 Do reciprocal interactions between cell stress proteins and cytokines create a new intra-/extra-cellular signalling nexus? [DOI]
148. 148 Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96 [DOI]
149. 149 Membrane and membrane‐associated proteins involved in the aggressive phenotype displayed by highly invasive cancer cells [DOI]
150. 150 Retraction Notice: Regulatory Chaperone Complexes in Neurodegenerative Diseases: A Perspective on Therapeutic Intervention [DOI]
151. 151 A C-terminal signal prevents secretion of luminal ER proteins [DOI]
152. 152 HSP90 at the hub of protein homeostasis: emerging mechanistic insights [DOI]
153. 153 Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications [DOI]
154. 154 Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex [DOI]
155. 155 Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition [DOI]
156. 156 The Regulation of Exosome Secretion: a Novel Function of the p53 Protein [DOI]
157. 157 Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness [DOI]
158. 158 Induction of heat shock proteins in B-cell exosomes [DOI]
159. 159 Inflammation and cancer: how friendly is the relationship for cancer patients? [DOI]
160. 160 Randomized Phase II Study of Erlotinib Plus Tivantinib Versus Erlotinib Plus Placebo in Previously Treated Non–Small-Cell Lung Cancer [DOI]
161. 161 Proteomic Analysis of Exosomes Secreted by Human Mesothelioma Cells [DOI]
162. 162 Phosphorylation of Serine 303 Is a Prerequisite for the Stress-Inducible SUMO Modification of Heat Shock Factor 1 [DOI]
163. 163 Extracellular heat shock protein‐90α: linking hypoxia to skin cell motility and wound healing [DOI]
164. 164 Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90 [DOI]
165. 165 Targeting the Molecular Chaperone Heat Shock Protein 90 Provides a Multifaceted Effect on Diverse Cell Signaling Pathways of Cancer Cells [DOI]
166. 166 Curcumin inhibits hepatitis C virus replication via suppressing the Akt‐SREBP‐1 pathway [DOI]
167. 167 The Assembly and Intermolecular Properties of the hsp70-Hop-hsp90 Molecular Chaperone Complex [DOI]
168. 168 Anti-Cancer Activities of Tea Epigallocatechin-3-Gallate in Breast Cancer Patients under Radiotherapy [DOI]
169. 169 Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer [DOI]
170. 170 Multiple Conformations of E. coli Hsp90 in Solution: Insights into the Conformational Dynamics of Hsp90 [DOI]
171. 171 Direct and Indirect Involvement of MicroRNA-499 in Clinical and Experimental Cardiomyopathy [DOI]
172. 172 Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation [DOI]
173. 173 HSP-molecular chaperones in cancer biogenesis and tumor therapy: an overview.
174. 174 Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies [DOI]
175. 175 Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2 [DOI]
176. 176 Identification of Residues on Hsp70 and Hsp90 Ubiquitinated by the Cochaperone CHIP [DOI]
177. 177 Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors [DOI]
178. 178 SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation [DOI]
179. 179 HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms [DOI]
180. 180 The heat‐shock protein receptors: some answers and more questions [DOI]
181. 181 Altered states: selectively drugging the Hsp90 cancer chaperone [DOI]
182. 182 Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition.
183. 183 KU135, a Novel Novobiocin-Derived C-Terminal Inhibitor of the 90-kDa Heat Shock Protein, Exerts Potent Antiproliferative Effects in Human Leukemic Cells [DOI]
184. 184 Geldanamycin, a Ligand of Heat Shock Protein 90, Inhibits the Replication of Herpes Simplex Virus Type 1 In Vitro [DOI]
185. 185 Molecular Chaperones as a Common Set of Proteins That Regulate the Invasion Phenotype of Head and Neck Cancer [DOI]
186. 186 Suppression of Survivin Induced by a BCR-ABL/JAK2/STAT3 Pathway Sensitizes Imatinib-Resistant CML Cells to Different Cytotoxic Drugs [DOI]
187. 187 Probing Molecular Mechanisms of the Hsp90 Chaperone: Biophysical Modeling Identifies Key Regulators of Functional Dynamics [DOI]
188. 188 The Non-canonical Hop Protein from Caenorhabditis elegans Exerts Essential Functions and Forms Binary Complexes with Either Hsc70 or Hsp90 [DOI]
189. 189 Curcumin inhibits human cytomegalovirus by downregulating heat shock protein 90 [DOI]
190. 190 Membrane-bound heat shock proteins facilitate the uptake of dying cells and cross-presentation of cellular antigen [DOI]
191. 191 Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts.
192. 192 A Purine Scaffold HSP90 Inhibitor BIIB021 Has Selective Activity against KSHV-Associated Primary Effusion Lymphoma and Blocks vFLIP K13-Induced NF-κB [DOI]
193. 193 Analysis of Nitroso-Proteomes in Normotensive and Severe Preeclamptic Human Placentas1 [DOI]
194. 194 A Functional Heat Shock Protein 90 Chaperone Is Essential for Efficient Flock House Virus RNA Polymerase Synthesis in Drosophila Cells [DOI]
195. 195 A microRNA-27a mimic sensitizes human oral squamous cell carcinoma HSC-4 cells to hyperthermia through downregulation of Hsp110 and Hsp90 [DOI]
196. 196 Heat shock protein 90 inhibitor NVP ‐ AUY 922 exerts potent activity against adult T‐cell leukemia–lymphoma cells [DOI]
197. 197 Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels [DOI]
198. 198 Coumermycin A1 inhibits growth and induces relaxation of supercoiled plasmids in Borrelia burgdorferi, the Lyme disease agent [DOI]
199. 199 Molecularchaperones as HSF1-specific transcriptional repressors [DOI]
200. 200 Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance [DOI]
201. 201 Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery [DOI]
202. 202 Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway [DOI]
203. 203 NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis [DOI]
204. 204 HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab [DOI]
205. 205 The HSP90 family of genes in the human genome: Insights into their divergence and evolution [DOI]
206. 206 mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis [DOI]
207. 207 Transforming Growth Factor α (TGFα)-Stimulated Secretion of HSP90α: Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGFβ-Rich Environment during Wound Healing [DOI]
208. 208 Curcumin inhibits hepatitis B virus via down‐regulation of the metabolic coactivator PGC‐1α [DOI]
209. 209 Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come [DOI]
210. 210 Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules [DOI]
211. 211 Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues [DOI]
212. 212 Herpes Simplex Virus Type 1 DNA Polymerase Requires the Mammalian Chaperone Hsp90 for Proper Localization to the Nucleus [DOI]
213. 213 In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors [DOI]
214. 214 The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90β gene by interleukin-6 but have opposite effects on its inducibility by heat shock [DOI]
215. 215 Extracellular Hsp90 (eHsp90) as the Actual Target in Clinical Trials [DOI]
216. 216 Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme [DOI]
217. 217 Heat-shock Protein 90 Is Essential for Stabilization of the Hepatitis C Virus Nonstructural Protein NS3 [DOI]
218. 218 A multicenter trial evaluating retaspimycin HCL (IPI-504) plus trastuzumab in patients with advanced or metastatic HER2-positive breast cancer [DOI]
219. 219 Heterogeneity and dynamics in the assembly of the Heat Shock Protein 90 chaperone complexes [DOI]
220. 220 Inhibition of Wee1, AKT, and CDK4 Underlies the Efficacy of the HSP90 Inhibitor XL888 in an In Vivo Model of NRAS -Mutant Melanoma [DOI]
221. 221 Nimotuzumab plus paclitaxel and cisplatin as the first line treatment for advanced esophageal squamous cell cancer: A single centre prospective phase II trial [DOI]
222. 222 Extracellular cell stress proteins as biomarkers of human disease [DOI]
223. 223 Geldanamycin, a Potent and Specific Inhibitor of Hsp90, Inhibits Gene Expression and Replication of Human Cytomegalovirus [DOI]
224. 224 Stimulation of the weak ATPase activity of human Hsp90 by a client protein 1 1Edited by G. von Heijne [DOI]
225. 225 Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC). [DOI]
226. 226 A phase II study of HSP90 inhibitor AUY922 and erlotinib (E) for patients (pts) with EGFR-mutant lung cancer and acquired resistance (AR) to EGFR tyrosine kinase inhibitors (EGFR TKIs). [DOI]
227. 227 Phase IB/II study of the HSP90 inhibitor AUY922, in combination with trastuzumab, in patients with HER2+ advanced breast cancer. [DOI]

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