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Research Article Open access CC BY 4.0

The Potential for Acupuncture to Attenuate Hippocampal Apoptosis

Hana Marsheck, Yunsuk Koh

Asian Journal of Medicine and Health · pp. 35–47 · Published 10 Mar 2020

10.9734/ajmah/2020/v18i130178

Abstract

Aims: To evaluate the potential for acupuncture to help mediate hippocampal apoptosis. Study Design: Systematic Review. Methodology: A search was conducted through PubMed, Scopus and Web of Science using the keywords “hippocampus,” “apoptosis” and “acupuncture” and found 37 qualified articles from January 2009 to March 2019. Results: All of the qualifying studies reviewed strongly support that acupuncture decreases the incidence of hippocampal apoptosis. Conclusion: It was clear that acupuncture can positively affect hippocampal apoptosis. The most frequently suggested mechanism was decreased BAX expression and increased BCL-2 expression, often in the CA1 region of the hippocampus, although it was only seen in about 1/3 of the studies reviewed. Future studies are needed to further investigate the exact mechanism associated with acupuncture in hippocampal apoptosis.

Brain ischemia BCL-2-associated X protein expression B-cell lymphoma 2 expressions p38 mitogen-activated protein kinase pathway.

References (15)

  1. 1 Apoptosis: A Review of Programmed Cell Death [DOI]
  2. 2 Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies [DOI]
  3. 3 Electroacupuncture pretreatment with different waveforms prevents brain injury in rats subjected to cecal ligation and puncture via inhibiting microglial activation, and attenuating inflammation, oxidative stress and apoptosis [DOI]
  4. 4 Acupuncture reduced apoptosis and up-regulated BDNF and GDNF expression in hippocampus following hypoxia–ischemia in neonatal rats [DOI]
  5. 5 The effects of the 5-HT7 receptor on hippocampal long-term potentiation and apoptosis in a rat model of Alzheimer’s disease [DOI]
  6. 6 Neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced damage and apoptosis in the rat hippocampus [DOI]
  7. 7 Reduced risk of apoptosis: mechanisms of stress responses [DOI]
  8. 8 Electroacupuncture relieves depression-like symptoms in rats exposed to chronic unpredictable mild stress by activating ERK signaling pathway [DOI]
  9. 9 Subchronic exposure to arsenic induces apoptosis in the hippocampus of the mouse brains through the Bcl‐2/Bax pathway [DOI]
  10. 10 Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia [DOI]
  11. 11 Lithium Treatment Prevents Apoptosis in Neonatal Rat Hippocampus Resulting from Sevoflurane Exposure [DOI]
  12. 12 Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway [DOI]
  13. 13 Acupuncture suppresses kainic acid-induced neuronal death and inflammatory events in mouse hippocampus [DOI]
  14. 14 Acupuncture Regulates the Unfolded Protein Response and Inhibits Apoptosis in a Rat Model of Heroin Relapse [DOI]
  15. 15 [Effect of Electroacupuncture Combined with Rehabilitation Training on Neurological Function and Expression of Neuronal Growth Associated Protein 43 and Synaptophysin in Rats with Focal Cerebral Ischemia/Reperfusion Injury].

Cited by 1

Acupuncture Readiness Attitude Scale (ARAS): An Informal Screener for Patient Suitability for Acupuncture Treatment

Guo-Hui Xie, Meng Kiat Tan, Jennifer Erin Camulli · Journal of Complementary and Alternative Medical Research · 2024

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