Skip to content
Research Article Open access CC BY 4.0

The Predictive Diagnostic and Prognostic Cut-off Values for Interleukin 8 in Patients with Meningitis in Egypt

M. Mosaad, M. Shedid, N. Soliman, M. Abdou, F. Amal, M. Gaber

International Journal of TROPICAL DISEASE & Health · pp. 57–65 · Published 2 May 2015

10.9734/IJTDH/2015/17884

Abstract

Objectives: This work was done to detect the best cut-off values for IL-8 to diagnose CNS infections (meningitis and meningio-encephalitis), to differentiate septic from aseptic types, and to predict mortality. Methods: A case- control series design was chosen, where 42 patients who were diagnosed clinically as having meningitis and 42 control subjects were subjected for lumbar puncture and their cerebrospinal fluids were examined physically, chemically, cytologically, and bacteriologically; besides the level of interleukin 8 (IL-8) was determined and compared for both groups. Results: The mean value of IL-8 was 75.8±89.1 in cases group compared to 26.2±18.0 in the control group which was highly statistically significant; its best significant cut off value for detection of CNS infection (meningitis or meningio-encephalitis) is 44ng/ml, while the best significant cut off value to diagnose septic meningitis was 50 with sensitivity of 52% and specificity of 82.35%. The mortality in our cases was 16.6%, and IL-8 best significant cut off value to detect this mortality was140 with sensitivity of 100% and specificity of 89.47% with +ve likelihood ratio 9.5. Conclusions: IL-8 in CSF is a valid good significant marker to diagnose the infection, differentiate septic from aseptic types besides the known parameters, and more over it significantly predicts mortality in cases with meningitis and meningio-encephalitis.

CSF Egypt interleukin-8 meningitis

References (34)

  1. 1 Practice Guidelines for the Management of Bacterial Meningitis [DOI]
  2. 2 Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8 [DOI]
  3. 3 A novel neutrophil-activating factor produced by human mononuclear phagocytes. [DOI]
  4. 4 Cerebrospinal Fluid in Diseases of the Nervous System. [DOI]
  5. 5 Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1). [DOI]
  6. 6 Bacterial meningitis in children [DOI]
  7. 7 Laboratory diagnosis of bacterial meningitis [DOI]
  8. 8 Burden of Encephalitis‐Associated Hospitalizations in the United States, 1988–1997 [DOI]
  9. 9 Diagnosis and treatment of bacterial meningitis [DOI]
  10. 10 Diagnosis of acute bacterial meningitis in children at a district hospital in sub-Saharan Africa [DOI]
  11. 11 Incidence and Prognosis of Central Nervous System Infections in a Birth Cohort of 12 000 Children [DOI]
  12. 12 DIFFICULT AND RECURRENT MENINGITIS [DOI]
  13. 13 The role of lumbar puncture in suspected CNS infection--a disappearing skill? [DOI]
  14. 14 Laboratory-based surveillance of patients with bacterial meningitis in Egypt (1998–2004) [DOI]
  15. 15 Cerebrospinal Fluid TNF-α, IL-6, and IL-8 in Children With Bacterial Meningitis [DOI]
  16. 16 Etiology, antimicrobial susceptibility profiles, and mortality associated with bacterial meningitis among children in Egypt [DOI]
  17. 17 Meningococcal disease in the Middle East and North Africa: an important public health consideration that requires further attention [DOI]
  18. 18 IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis [DOI]
  19. 19 Role of Cerebrospinal Fluid Il-8 as a Marker for Differentiation between Acute Bacterial and Aseptic Meningitis [DOI]
  20. 20 Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system.
  21. 21 CLINICAL PRESENTATIONS, DIAGNOSIS, AND PROGNOSTIC FACTORS OF BACTERIAL MENINGITIS [DOI]
  22. 22 Interleukin-8 in Cerebrospinal Fluid from Patients with Meningitis of Different Etiologies: Its Possible Role as Neutrophil Chemotactic Factor [DOI]
  23. 23 Performance of a predictive rule to distinguish bacterial and viral meningitis [DOI]
  24. 24 CEREBROSPINAL FLUID TESTING FOR THE DIAGNOSIS OF CENTRAL NERVOUS SYSTEM INFECTION [DOI]
  25. 25 Pooled Analysis of 2,408 Cases of Acute Adult Purulent Meningitis from Turkey [DOI]
  26. 26 Interleukin-8 in cerebrospinal fluid from patients with septic and aseptic meningitis [DOI]
  27. 27 Increased Levels of Cytokines in Cerebrospinal Fluid of Children with Aseptic Meningitis Caused by Mumps Virus and Echovirus 30 [DOI]
  28. 28 Cerebrospinal Fluid Cell Counts and Chemistries in Bacterial Meningitis [DOI]
  29. 29 Management of bacterial meningitis [DOI]
  30. 30 Cerebral Spinal Fluid [DOI]
  31. 31 Rapid diagnosis of bacterial meningitis by latex agglutination test.
  32. 32 Concentrations of Interleukin-1.BETA., Interleukin-6, Interleukin-8 and TNF-.ALPHA. in Cerebrospinal Fluid from Children with Septic or Aseptic Meningitis. [DOI]
  33. 33 Serial Measurement of Anti-interleukin-8 IgG Autoantibody in Cerebrospinal Fluid of Infants with Bacterial Meningitis [DOI]
  34. 34 [The role of cytokines in bacterial meningitis].

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

1

Page views

0

PDF downloads

0

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.