The Prevalence of Cholelithiasis in Nigerians with Sickle Cell Disease as Diagnosed by Ultrasound
C. A. Agholor, A. O. Akhigbe, O. M. Atalabi
Journal of Advances in Medicine and Medical Research · pp. 2866–2873 · Published 6 Mar 2014
10.9734/BJMMR/2014/8645Abstract
Aim: To determine the prevalence of cholelithiasis in Nigerians with sickle cell disease in steady state, using ultrasonography. Study Design: A prospective cross-sectional study. Place and Duration of Study: Haematology Clinic, University of Benin Teaching Hospital, Benin City and Sickle Cell Centre, Benin City, Nigeria between July and December 2011. Methodology: The study population was made up of non-pregnant sickle cell disease patients not in crisis and who have not had cholecystectomy. They were confirmed to have sickle cell disease through haemoglobin electrophoresis. All the patients were examined with a B-mode ultrasound machine with a curvilinear multifrequency transducer 2.5-7.5MHZ after an overnight or at least six hour fast. Calculi were diagnosed if highly echogenic structures, with acoustic shadowing were detected in the lumen of the gallbladder. Results: There were 79 females and 71 males, aged between 10 months and 51 years. Of the 150 patients, 140 were homozygous for sickle cell disease (HbSS), while the remaining 10 were heterozygous for sickle cell disease (HbSC). The prevalence of cholelithiasis was 16.0%. It was related to age, sex and haemoglobin genotype. There was progressive increase in cholelithiasis with age which was more pronounced in the third and fourth decades. Cholelithiasis was also significantly more commonly seen in the HbSS group 23 (16.4%) out of 140 patients compared with the HbSC group 1 (10.0%) out of 10 patients. Cholelithiasis did not correlate with sex, although it was more commonly observed in females. The youngest patient with gall stones in this study was 2 years. Conclusion: The prevalence of cholelithiasis in Nigerians with sickle cell disease was 16.0% and it was related to age and haemoglobin genotype.
Cited by 29
Oyomi J. K, Irabor P. F. I, Eluehike S. U, Akhigbe A. O, Izevbekhai S. O · International Journal of TROPICAL DISEASE & Health · 2024
Ademola Samson Adewoyin · Anemia · 2015
Adel Homoud Almudaibigh, Fawaz Abdulaziz Alkasim, Eatidal Fathey Ghareeb · Journal of Applied Hematology · 2021
Ayomikun Ajani, Iliya Jalo, Suleiman Tanimu Saad · Open Journal of Pediatrics · 2019
PhilipC Okere, EnyereibeC Ajare, AugustineC Onuh · Nigerian Journal of Medicine · 2020
Osaigbovo Emmanuel Ighodaro · International Journal of Medicine and Health Development · 2022
Hammed Ninalowo, Aderemi Oluyemi, Chidubem Ugwueze · Journal of Radiation Medicine in the Tropics · 2022
Sagad O O Mohamed, Omer A O Ibrahim, Dahlia A A Mohammad · JGH Open · 2021
Obi Peter Adigwe, Godspower Onavbavba, Solomon Oloche Onoja · International Journal of General Medicine · 2023
Mohamed Adam, Mustafa Musa, Saleh Al-Qahtani · International Journal of General Medicine · 2023
Showing 14 of 29 known citations — external sources report more than can currently be individually listed.
Related research
- Common Findings in Ultrasound Examination of the Liver and Kidney in Sokoto Metropolis — shares topic coverage
- Ultrasonography as a Tool in Assessment of Breast Pain among Women — shares topic coverage
- A Case Report of Breast Myofibroblastoma: A Bad Looking Benign Tumor — shares topic coverage
- Diagnostic Utility of Lipid Indices for Detecting MASLD in Patients with Metabolic Syndrome — shares topic coverage
- Ultrasonic for Reducing Tetracycline Residues in Acacia Honey and Its Impact on Physicochemical Properties — shares topic coverage
Article metrics
Real usage data collected on this platform.
16
Page views
0
PDF downloads
1
Outbound clicks
29
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.