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Research Article Open access CC BY 4.0

Tumor Necrosis Factor Receptor II Gene Polymorphism and Association with Plasmodium falciparum Malaria in Badagry, Lagos, Nigeria

Onyinye Celestina Okoyenta, Ngozi Awa Imaga, Oluwagbemiga Olanrewaju Aina, Olusola Ajibaye

International Journal of Biochemistry Research & Review · pp. 32–42 · Published 2 Jul 2022

10.9734/ijbcrr/2022/v31i530323

Abstract

Host genetic factors, host-parasite interactions, parasite genetic diversity, and/or environmental influences have been implicated in the molecular basis of susceptibility and resistance to Plasmodium parasite infections. Host Tumor Necrosis Factor Receptor II (TNFR II), a 75/80kDa protein encoded by the tnfr II gene has been identified as an adhesion protein for Plasmodium falciparum parasite. Tnfr II gene exhibits functional polymorphism on exon 6 among Caucasians with a potential effect on the ligand-binding function of TNFR II. This study aimed to investigate tnfr II gene polymorphisms on exon 6 and its relationship to Plasmodium falciparum malaria in Badagry, Lagos Nigeria. Genotyping was done using PCR-Restriction fragment length polymorphism assay. A total of 68 blood samples comprising of 49 controls and 19 malaria cases were genotyped. Result revealed both the wild-type (T587) and a mutant-type (T→587G) genotypes of tnfr II. Generally, the analysis showed that the variant-type had a lower prevalence rate (11.76%) than the wild-type (88.24%). The frequencies of wild-type were highest in the controls (85.70%) while the frequencies of the mutant-type were lower in the malaria cases (5.30%). However, the Chi-square test showed no statistical significant difference (p value = 0.30) between the distribution of the genotypes in malaria cases and controls. This study indicates that polymorphism on exon 6 of tnfr II gene was not associated with susceptibility or resistance to malaria infection in Badagry, Nigeria. Further researches with a larger sample size are needed to clarify this subject.

Gene polymorphisms tumor necrosis factor receptors malaria tnfr II genes Plasmodium falciparum genotypes parasite antigens genetic factors

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