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Research Article Open access CC BY 3.0

Vagus Nerve Versus Helicobacter pylori: New View on Old Secrets of Gastroduodenal Pathology

Oksana Sulaieva

Annual Research & Review in Biology · pp. 3392–3408 · Published 16 Jun 2014

10.9734/ARRB/2014/10227

Abstract

Despite the long history of research on etiology and pathogenesis of gastroduodenal pathology, there are still a lot of unclear points in this field. Identification of Helicobacter pylori has been widely considered to be a major breakthrough in pathophysiology of gastroduodenal diseases. However, Helicobacter pylori infection, as a host-pathogen interaction, involves bidirectional cross-talk and requires assessment not only in terms of Helicobacter pylori virulence, but the immune reactivity of the host too. One of the major tasks of mucosal immunity is to discriminate between dangerous and harmless antigens, and it depends on neuroimmune cross-talk, which is orchestrated in gastroduodenal area by vagus nerve. In this review, we propose to recall and assess the role of the vagus nerve in the gastroduodenal homeostasis maintenance and anti-Helicobacter pylori fight, focusing on Helicobacter pylori-gastric mucosa-vagus nerve interaction. The following issues are discussed in this review: 1) Vagus nerve regulation of mucins production as a key element of gastrointestinal barrier against Helicobacter pylori colonization; 2) Virulence factors of Helicobacter pylori and cytoprotective effects of vagus nerve; 3) Peculiarities of Helicobacter pylori-induced innate immunity response, involving host cytokine network activation, and vagus nerve effects, realized through cholinergic anti-inflammatory pathway; 4) Modulation of maturation and activity of dendritic cells by Helicobacter pylori and acetylcholine; and 5) Alteration of adaptive immunity during Helicobacter pylori infection and role of acetylcholine. The structural and immune homeostasis of gastroduodenal area can be affected not only by Helicobacter pylori virulence factors, but theoretically by any shifting in vagus nerve reactivity and/or interaction with enteroendocrine and immune cells in gastroduodenal mucosa.

Vagus nerve Helicobacter pylori acetylcholine mucosal immunity.

References (76)

  1. 1 Toll-like receptors: critical proteins linking innate and acquired immunity [DOI]
  2. 2 Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation [DOI]
  3. 3 Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit [DOI]
  4. 4 Reflex control of immunity [DOI]
  5. 5 Mechanisms of disease: Helicobacter pylori virulence factors [DOI]
  6. 6 Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori [DOI]
  7. 7 Living dangerously: how Helicobacter pylori survives in the human stomach [DOI]
  8. 8 Control of Gastric Acid Secretion in Health and Disease [DOI]
  9. 9 Helicobacter pylori Immune Escape Is Mediated by Dendritic Cell–Induced Treg Skewing and Th17 Suppression in Mice [DOI]
  10. 10 Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis [DOI]
  11. 11 Optimal therapy for Helicobacter pylori infections [DOI]
  12. 12 The Neurology of the Immune System: Neural Reflexes Regulate Immunity [DOI]
  13. 13 Lymphocyte-derived ACh regulates local innate but not adaptive immunity [DOI]
  14. 14 Neural aspects of immunomodulation: Focus on the vagus nerve [DOI]
  15. 15 Muc1 Mucin Limits Both Helicobacter pylori Colonization of the Murine Gastric Mucosa and Associated Gastritis [DOI]
  16. 16 Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function [DOI]
  17. 17 Neuro-immune interactions via the cholinergic anti-inflammatory pathway [DOI]
  18. 18 Immune modulation of the brain-gut-microbe axis [DOI]
  19. 19 Gastrointestinal Inflammation: A Central Component of Mucosal Defense and Repair [DOI]
  20. 20 Helicobacter pylori research: historical insights and future directions [DOI]
  21. 21 The Gut’s Little Brain in Control of Intestinal Immunity [DOI]
  22. 22 The lymphocytic cholinergic system and its biological function [DOI]
  23. 23 The Gastric H,K ATPase as a Drug Target [DOI]
  24. 24 Inflammatory Mediators in Gastrointestinal Defense and Injury [DOI]
  25. 25 Aberrant expression of gland-type gastric mucin in the surface epithelium of Helicobacter pylori-infected patients [DOI]
  26. 26 Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of naïve CD4 T cells toward the Th1, Th2 and Th17 lineages [DOI]
  27. 27 Human primary gastric dendritic cells induce a Th1 response to H. pylori [DOI]
  28. 28 Immune responses toHelicobacter pyloricolonization: mechanisms and clinical outcomes [DOI]
  29. 29 Human Gastric Mucins Differently Regulate Helicobacter pylori Proliferation, Gene Expression and Interactions with Host Cells [DOI]
  30. 30 Differential involvement of α4β2, α7 and α9α10 nicotinic acetylcholine receptors in B lymphocyte activation in vitro [DOI]
  31. 31 Helicobacter pylori Infection Impairs the Mucin Production Rate and Turnover in the Murine Gastric Mucosa [DOI]
  32. 32 Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells [DOI]
  33. 33 Effects of Helicobacter pylori Eradication on Gastroesophageal Reflux Disease [DOI]
  34. 34 Natural Competence Promotes Helicobacter pylori Chronic Infection [DOI]
  35. 35 Cholinergic modulation of dendritic cell function [DOI]
  36. 36 Pathophysiological functions of the CagA oncoprotein during infection by Helicobacter pylori [DOI]
  37. 37 Stimulation of dendritic cells with Helicobacter pylori vacuolating cytotoxin negatively regulates their maturation via the restoration of E2F1 [DOI]
  38. 38 Bacterial chemotaxis modulates host cell apoptosis to establish a T-helper cell, type 17 (Th17)-dominant immune response in Helicobacter pylori infection [DOI]
  39. 39 Brainstem Neuropeptides and Vagal Protection of the Gastric Mucosal Against Injury: Role of Prostaglandins, Nitric Oxide and Calcitonin-Gene Related Peptide in Capsaicin Afferents [DOI]
  40. 40 Current pharmacotherapy options for gastritis [DOI]
  41. 41 Regulatory mechanism of duodenal bicarbonate secretion [DOI]
  42. 42 ATRA alters humoral responses associated with amelioration of EAMG symptoms by balancing Tfh/Tfr helper cell profiles [DOI]
  43. 43 Differentiation of the Gastric Mucosa I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes [DOI]
  44. 44 Cholinergic signalling in gut immunity [DOI]
  45. 45 Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells [DOI]
  46. 46 Positive T cell co-stimulation by TLR7/8 ligands is dependent on the cellular environment [DOI]
  47. 47 Prostaglandins inhibit secretion of histamine and pancreastatin from isolated rat stomach ECL cells [DOI]
  48. 48 The Future of the Pump [DOI]
  49. 49 Adaptive Cytoprotection and the Brain-Gut Axis [DOI]
  50. 50 From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
  51. 51 Pathogenesis of Helicobacter pylori Infection [DOI]
  52. 52 Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway [DOI]
  53. 53 Helicobacter pylori Vacuolating Cytotoxin Inhibits T Lymphocyte Activation [DOI]
  54. 54 Helicobacter pylori moves through mucus by reducing mucin viscoelasticity [DOI]
  55. 55 A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen [DOI]
  56. 56 Reflex Principles of Immunological Homeostasis [DOI]
  57. 57 Pathogenesis of Helicobacter pylori infection [DOI]
  58. 58 The vagal innervation of the gut and immune homeostasis [DOI]
  59. 59 Mucosal FOXP3 -Expressing CD4 + CD25 high Regulatory T Cells in Helicobacter pylori -Infected Patients [DOI]
  60. 60 Helicobacter pylori -induced peptic ulcer disease is associated with inadequate regulatory T cell responses [DOI]
  61. 61 Gut hormones: emerging role in immune activation and inflammation [DOI]
  62. 62 The Influence of Mucus Microstructure and Rheology in Helicobacter pylori Infection [DOI]
  63. 63 Molecular cross-talk between Helicobacter pylori and human gastric mucosa [DOI]
  64. 64 Inflammatory Mediators in Gastrointestinal Defense and Injury [DOI]
  65. 65 Helicobacter pylori and mucosa-associated lymphoid tissue: what's new [DOI]
  66. 66 Cholinergic Regulatory Lymphocytes Re-Establish Neuromodulation of Innate Immune Responses in Sepsis [DOI]
  67. 67 Gastric mucosal cytokine responses inHelicobacter pylori-infected patients with gastritis and peptic ulcers. Association with inflammatory parameters and bacteria load [DOI]
  68. 68 Physiological and clinical significance of enterochromaffin-like cell activation in the regulation of gastric acid secretion [DOI]
  69. 69 Dendritic cell function in the host response toHelicobacter pyloriinfection of the gastric mucosa [DOI]
  70. 70 Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice [DOI]
  71. 71 Neurogenic regulation of dendritic cells in the intestine [DOI]
  72. 72 IsHelicobacter pyloriInfection the Primary Cause of Duodenal Ulceration or a Secondary Factor? A Review of the Evidence [DOI]
  73. 73 Gastric Mucosal Protection And Central Nervous System [DOI]
  74. 74 Gastric Mucosal Protection And Central Nervous System [DOI]
  75. 75 [Inflammation as a basis for Helicobacter pylori-associated diseases].
  76. 76 From Prout to the proton pump--a history of the science of gastric acid secretion and the surgery of peptic ulcer.

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