Valproate and Pediatric Stevens-Johnson Syndrome: A Critical Alert
Jafrin Sadiq Abdul Razack, Syeda Juveria Hussaini, Saud Khaled Aldoseri, Hisham Abubacker Musthafa, Antony Calvin Ossanam, Ibtisam Akram, Sahil Asgar Ali, Mohamed Ahmed Ebrahim Ahmed Abdulla, Vivek Karan
International Journal of Medical and Pharmaceutical Case Reports · pp. 35–38 · Published 20 Jul 2024
10.9734/ijmpcr/2024/v17i3389Abstract
Stevens-Johnson Syndrome is a severe condition that affects the skin and mucous membranes, often caused by medications or infections. This case study details the experience of a three-year-old boy who developed SJS after beginning valproate treatment for seizure management following a traumatic brain injury. Initially, he showed symptoms of fever, facial redness, and a runny nose, which progressed to a severe rash and blisters. A dermatologist confirmed the diagnosis of SJS linked to valproate. Swift diagnosis, discontinuation of the offending drug, and supportive care are essential in managing SJS and preventing serious complications. Early intervention and comprehensive care from a variety of medical professionals are crucial for improving patient outcomes.
References (5)
- 1 Lamotrigine and Stevens-Johnson Syndrome Prevention [DOI]
- 2 Toxic Epidermal Necrolysis (TEN)/Stevens-Johnson Syndrome (SJS) Epidemiology and Mortality Rate at King Fahad Specialist Hospital (KFSH) in Qassim Region of Saudi Arabia: A Retrospective Study [DOI]
- 3 Ocular Manifestations of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis [DOI]
- 4 Steven-Johnson Syndrome Induced by Lamotrigine and Valproic Acid in a Pediatric Patient: A Case Report [DOI]
- 5 Toxic Epidermal Necrolysis [DOI]
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