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All published articles 7450

Phytochemical Screening and Antioxidant Activity of Salvia hispanica

Hanane Dib, Meryem Seladji, Fatima Zohra Bencheikh, Meriem Faradji, Chahid Benammar & Meriem Belarbi · Journal of Pharmaceutical Research International · 2021

Background: There is a growing interest worldwide to identify novel functional foods able to exert important biochemical activities with low or without toxic effect. Accordingly, the use of Salvia hispanica L. (chia) a Mexican herb, has tremendously grown as an agriculture crop o...

Open access Research Article 10.9734/jpri/2021/v33i41A32314

Analysis between Cigarette and Shisha Smokers for Early Atherogenesis: A Cardiovascular Disease

Danish Iqbal, Izhar Wasif Burhan, Ranjay Kumar Choudhary, Mohammed Alaidarous, Bader Mohammed Alshehri, Saeed Banawas & Shabir Ahmad Mir · Journal of Pharmaceutical Research International · 2021

Aims: Tobacco smoking is a major health issue in Saudi Arabia, particularly among the student population. Smoking is one of the major risk factors in the genesis of coronary atherosclerosis and the development of coronary heart disease. This study aimed to evaluate the effect of...

Open access Research Article 10.9734/jpri/2021/v33i41A32316

Tenofovir Alafenamide Fumarate Microspheres, Process Parameters for Enhanced Permeability and Liver Targeting

K. Sudhamani & B. Jeevana Jyothi · Journal of Pharmaceutical Research International · 2021

Aims: Chronic hepatitis B (CHB) infection is a serious global health problem and one of the main causes of chronic liver disease, cirrhosis. Tenofovir Alafenamide Fumarate (TAF) is a prodrug of Tenofovir, a nucleotide analogue with limited oral bioavailability. TAF is considered...

Open access Research Article 10.9734/jpri/2021/v33i41A32317

The Content, Antioxidant Activity, and Structural Characteristics of Sodium Alginate Extracting from Sargassum polycystum Grew in Vietnam: Effect of Various Extraction Conditions

Nguyen Dinh Thuat, Vu Ngoc Boi, Nguyen Xuan Hoan, Dang Thi Thanh Tuyen, Do Thuy Kieu, Nguyen Kim Nguyen, Nguyen Ngoc Bao Huy, Pham the Trinh, Pham Thanh Thuan & Dang Xuan Cuong · Journal of Pharmaceutical Research International · 2021

Introduction: Alginate is a biopolymer commonly in brown algae, high content, diversity in structure and bioactivity. They are applied to other fields such as food, functional food, pharmaceuticals, and heavy industry and extracted from Sargassum, Laminarin, Tubinaria and Sargass...

Open access Research Article 10.9734/jpri/2021/v33i41A32318

Prevalence of Sub-Clinical Hypothyroidism in Diagnosed Cases of Gallstone Disease

C. Kamalakkhannan · Journal of Pharmaceutical Research International · 2021

Thyroid issues have long been debated as a possible cause of gall stone disease. The link between hypothyroidism and gallstone disease could be explained in a variety of ways. The main objective of this study is to determine the prevalence of hypothyroidism in gallstone patients...

Open access Research Article 10.9734/jpri/2021/v33i41A32319

The Effect of Ethanol Extract of Carica papaya Seed towards Lipid Profile on Rats Induced Rifampicin and Isoniazid

. Liana, I. Nyoman Ehrich Lister, Edy Fachrial & . Adrian · Journal of Pharmaceutical Research International · 2021

Aims: Rifampicin one of the most commonly used front-line drugs in antituberculosis therapy, has been known to be hepatotoxic. The oxidative stress that is formed in the mitochondria due to rifampicin and isoniazid causes an imbalance in lipid metabolism. This study aims to deter...

Open access Research Article 10.9734/jpri/2021/v33i41A32320

Dapsone Induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome - A Case Report

Safi Eldin E. Ali, Osama M. Ibrahim & Sami F. Abdalla · Journal of Pharmaceutical Research International · 2021

A 50-year-old male Sudanese patient presented with a three-week history of jaundice, high-grade fever, and mucocutaneous eruption. For last months he was on compound therapy for leprosy, which had been confirmed recently. The patient’s face was prominent, along with the erythemat...

Open access Research Article 10.9734/jpri/2021/v33i41A32309

Malnutrition and Some Related Factors in Primary School Children in Saudi Arabia: Systemic Review

Hassan Tag Elkhatim Mohamed, Fahad Salamah Obaid Alanazi, Salah Farhan T. Alanazi, Mohammed Naif H. Aljuraysi & Omar Ayed B. Alanazi · Journal of Pharmaceutical Research International · 2021

Background: Malnutrition is an underlying factor in many diseases in both children and adults, and it contributes greatly to the disability-adjusted life years worldwide. It is a major public health concern in developing countries among children since it places a heavy burden on...

Open access Research Article 10.9734/jpri/2021/v33i41A32310

Prevalence and Expression of Genes of Type II Antitoxin Toxin Systems in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

M. Rahimkhani, A. Mordadi, P. Karami & O. Zarei · Journal of Pharmaceutical Research International · 2021

Objectives: Antibiotic resistance of bacteria has been increasing in recent years and reports indicate that some bacterial strains are even resistant to the last treatment line. The survey of MazEF antitoxin-toxin genes in 84 strain of MRSA and and the antimicrobial effect of sup...

Open access Research Article 10.9734/jpri/2021/v33i41A32307

A Cross Sectional Study to Assess the Status of Hemoglobin and Other Blood Indices among Pregnant Women Attending Tertiary Care Hospital of Vadodara

Vruti Patel & J. D. Lakhani · Journal of Pharmaceutical Research International · 2021

Introduction: A number of adaptations happen in the anatomy, physiology and metabolic processes within the mother which aids in successful progression of the pregnancy. The different blood indices such as haemoglobin concentration, packed cell volume (PCV), red blood cell count;...

Open access Research Article 10.9734/jpri/2021/v33i41A32308

Capsaicin Encapsulated Chitosan Nanoparticles Augments Anticarcinogenic and Antiproliferative Competency Against 7,12 Dimethylbenz(a)anthracene Induced Experimental Rat Mammary Carcinogenesis

Kalaiyarasi Dhamodharan, Manobharathi Vengaimaran & Mirunalini Sankaran · Journal of Pharmaceutical Research International · 2021

Background: Capsaicin is a powerful phytochemical spotted in chilies, starkly tied up with a bunch of health benefits but its clinical applications in cancer therapy are limited due to its poor solubility, and low bioavailability. Nanotechnology offers a strategy to discover new...

Open access Research Article 10.9734/jpri/2021/v33i41A32311

Effects of Spider Cage Therapy in Combination with Conventional Speech Therapy on Speech and Language Function in Children with Cerebral Palsy of Age between 05 and 15 Years

Fahad Masood, Muhammad Sikander Ghayas Khan, Farjad Afzal, Amna Rashid & Saba Mubarak · Journal of Pharmaceutical Research International · 2021

Objective: The objective of study was to determine the effects of spider cage therapy in combination with conventional speech therapy on speech and language function in children with cerebral palsy of age between 05 And 15 Years. Materials and Methods: A total of 20 children from...

Open access Research Article 10.9734/jpri/2021/v33i41A32312

In-vitro Cytoprotective Activity of Eichhornia crassipes Flowers Against Hydrogen Peroxideinduced Oxidative Stress in BRL 3A Rat Liver Cells

S. Rajarajan, S. Sivakrishnan & V. Ganesan · Journal of Pharmaceutical Research International · 2021

The aim of this study was to investigate the cytoprotective effect of ethanol extract of Eichhornia crassipes flowersand its fractions against hydrogen peroxide induced oxidative stress in BRL 3A liver cells. Powdered flowers of Eichhornia crassipeswere subjected to hot continuou...

Open access Research Article 10.9734/jpri/2021/v33i41A32313

The Role of SGLT-2 Inhibitors as an Adjuvant to Insulin Therapy in Type-1 Diabetes Mellitus- Literature Review

Sultan Ali Alshehri, Sultan Abdulwahab M. Asiri, Aalaa Mohammad Algarni & Manal Mohammed Alamari · Journal of Pharmaceutical Research International · 2021

Background: Type 1 diabetes mellitus is the main risk factor for cardiovascular complications. Therefore, intensified insulin therapy might be needed to achieve better glycemic control in some patients. However, insulin therapy might lead to increase body weight and induce hypogl...

Open access Research Article 10.9734/jpri/2021/v33i40B32295

Development and Validation of Novel RP-HPLC Method for the Simultaneous Determination of Remogliflozin and Vildagliptin in Bulk and in synthetic Mixture

Drashti A. Mandale, Chainesh Shah & Rakesh Jatt · Journal of Pharmaceutical Research International · 2021

Vildagliptin which is DPP-4 inhibitor and Remogliflozin which is SGLT2 inhibitor in single dose regimen lower blood glucose by separate, complementary mechanisms. Both are glucose dependent, accounting for the low risk of hypoglycaemia during treatment. There is no risk factors a...

Open access Research Article 10.9734/jpri/2021/v33i40B32296