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All published articles 7450

Clinical and Humanistic Outcomes of Tuberculosis Treatment in a Nigerian Directly Observed Treatment Short Course Centre

D. W. Dayom, M. K. Madison, M. A. Adeniyi, B. N. Joseph, C. N. Sariem, S. G. Mohammed & A. P. Lomak · Journal of Pharmaceutical Research International · 2020

Background: Tuberculosis remains a major global health problem. It causes ill-health among millions of people each year and ranks alongside the human immunodeficiency virus (HIV) as a leading cause of death worldwide. The objective of the study was to evaluate the clinical and hu...

Open access Research Article 10.9734/jpri/2020/v32i1130497

COVID-19, Various Treatment Options and Special Considerations for Dentistry

Smita Singh Bhardwaj, Sami Alduwayhi & Atul Bhardwaj · Journal of Pharmaceutical Research International · 2020

Objective: The aim of this article is to analyze the epidemiology of COVID-19, comparison of routes of transmission in children and adults, comparing the clinical symptoms in adults and children, treatment protocol to be followed and possible treatment options during this pandemi...

Open access Research Article 10.9734/jpri/2020/v32i1030494

Impact of Foeniculum vulgare Fortified Diet on Coagulation Profile and Some Biochemical Parameters

Afshan Abbas, Rahila Ikram, Faiza Hasan, Qurrat Ul Ain Bukhari, Sana Sarfaraz & Abeer Adil · Journal of Pharmaceutical Research International · 2020

Aims: Coagulation profile shows the clotting ability of blood. Biochemical tests indicate health status of vital organs such as liver, heart and kidneys. Herbal products are being assessed for their role in affecting these parameters. We evaluated role of Foeniculum vulgare incor...

Open access Research Article 10.9734/jpri/2020/v32i1030495

Metformin as an Adjuvant Therapy Attenuates Dextran Sulphate Sodium-induced Acute Colitis in Rats

Rania M. Magadmi, Fahad H. Aljahdali, Mustafa Alsawy, Ahmed S. Ali & Fatemah O. Kamel · Journal of Pharmaceutical Research International · 2020

Aims: In numerous cases, patients with inflammatory bowel diseases (IBDs) are refractory to standard treatment. Sirolimus (SIR) and tacrolimus (TAC) are immunosuppressant drugs with encouraging outcomes. However, they have side effects causing limitations in their use. Metformin...

Open access Research Article 10.9734/jpri/2020/v32i1030496

A Histopathological Study of Cisplatin-induced Acute Vascular Injuries in Vital Organs and Protective Effect of Achillea millefolium

Zahra Eslamifar & Susan Sabbagh · Journal of Pharmaceutical Research International · 2020

The aim was to study the protective effect of ethanolic extract of Achillea millefolium on acute vascular injuries induced by cisplatin in liver, heart and renal tissues 24 hour after administration and using histopathological surveys in wistar rats. 24 adult male wistar rats wer...

Open access Research Article 10.9734/jpri/2020/v32i1030493

Common Drugs with Effective Off-Label Uses

Mohammed M. Alshehri & Mahmoud M. E. Mudawi · Journal of Pharmaceutical Research International · 2020

The term off-label drug use (OLDU) is utilized broadly in the medical literature. It is a polarizing term since it may be related to incredible advantage or harm to patients. OLDU is defined as drug uses that not included in the indications or dosage regimens listed in the drug l...

Open access Research Article 10.9734/jpri/2020/v32i1030490

Analysis of Reported E-prescribing Medication Administration Errors at King Saud Medical City, Riyadh: A Cross-Sectional, Retrospective Study

Dalal Salem Al- Dossari, Mohammed Ibrahim Alnami & Naseem Akhtar Qureshi · Journal of Pharmaceutical Research International · 2020

Background: Drug prescription error is a medication error that most frequently happens in healthcare organizations and adversely affects the healthcare consumers. Most medication errors (MEs) but not all are captured and corrected before reaching the patient by designed system co...

Open access Research Article 10.9734/jpri/2020/v32i1030491

Hematological Changes and Antidiabetic Activities of Colocasia esculenta (L.) Schatt Stem Tuber Aqueous Extract in Alloxan Induced Diabetic Rats

Nwaogwugwu, Joel . Caleb, Uhegbu, F. O., Okereke, S. C., Nosiri, C. I., Amaka, E. N. & Idume Joy Nwamaka · Journal of Pharmaceutical Research International · 2020

Management of blood glucose level is the hallmark in the treatment of diabetes. Much work has not been done on the management of diabetes using the stem tuber extract of Colocasia esculenta. The objective of this study was to evaluate the antihyperglycemic and hematological param...

Open access Research Article 10.9734/jpri/2020/v32i1030487

Formulation and in vitro Characterization of Donepezil-loaded Chitosan Nanoparticles

Muhammad Wahab Amjad & Nawaf Mohamed Alotaibi · Journal of Pharmaceutical Research International · 2020

Millions of people are affected globally by alzheimer’s disease and it is regarded as a dangerous progressive medical and socio-economic burden. The drug delivery to brain is hindered due to the presence of blood brain barrier. Nanoparticle mediated drug delivery is a promising a...

Open access Research Article 10.9734/jpri/2020/v32i1030488

Assessment of the Dermal Acute Irritation Potential of Natural Veterinary Medicine Minyak Rajas in Albino Rabbits

I Made Merdana, Anak Agung Gde Arjana, Sri Kayati Widyastuti, Tisa Tetrania, Ketut Budiasa, Luh Made Sudimartini & I Wayan Sudira · Journal of Pharmaceutical Research International · 2020

Aims: This study was designed to assess the potential for acute dermal irritation of natural veterinary medicine Minyak Rajas (produce by Songgolangit Persada Limited Company, Bali, Indonesia) in albino rabbits. It is a rather thick liquid which contains various medicinal herbal...

Open access Research Article 10.9734/jpri/2020/v32i1030489

Phenolic Content and Enzyme Inhibition Activities Barbarea auriculata var. paludosa, B. integrifolia and B. plantaginea (Brassicaceae)'s

Merve Badem, Sıla Ozlem Sener, Nuriye Korkmaz, Seyda Kanbolat, Sermet Yildirmiş, Ufuk Ozgen, Rezzan Aliyazicioglu & Ali Kandemir · Journal of Pharmaceutical Research International · 2020

Barbarea genus has been presented about 12 species, 9 taxon are endemic, in Turkey. In this sudy, enzyme inhibition was carried out on methanolic extract, chloroform extract, ethyl acetate extract, and the remaining aqueous phases from the aerial parts of B. auriculata var paludo...

Open access Research Article 10.9734/jpri/2020/v32i930486

Kewda (Pandanus odorifer) Flower Derived Phytochemicals against Salutaridine Reductase of Hepatitis Virus Causing Hepatitis A

Pratyasa Pradhan, Nibedita Patra, Subhadra Manjari Parida, Hrudaya Ballava Dash, Bhagyeswari Behera & Srimay Pradhan · Journal of Pharmaceutical Research International · 2020

Pandanus odorifer plant extract is traditionally used to cure Hepatitis A. It is caused by Hepatitis virus. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that 1, 2, 3-benzene t...

Open access Research Article 10.9734/jpri/2020/v32i930542

Salvia rosmarinus Derived Phytochemicals against Eczema

Elora Barik, Selina Swain, Bibhuprasad Mishra, Kalpita Bhatta, Sasmita Mallick & Pratibha Karmee · Journal of Pharmaceutical Research International · 2020

The bioactive or phytochemicals substance from the plant Salvia rosmarinus helps in the prevention of eczema. Staphylococcus aureus is the causal organism for this disease. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy...

Open access Research Article 10.9734/jpri/2020/v32i930537

Potency of Phytochemicals from Guava (Psidium guajava) Seeds against Escherichia coli to Cure Diarrhoea: An in silico Analysis

Barsha Nayak, Lopita Mishra, Bibhu Prasad Mishra, Srimay Pradhan, Bhagyeswari Behera & Mukundjee Pandey · Journal of Pharmaceutical Research International · 2020

Machine learning to deep learning is the enduring upgrading in the pharmaceutical research field. Phytochemicals from Psidium guajava plant extract are traditionally used to cure Diarrhoea. The causative agent of the disease is Escherichia coli. To identify the secondary metaboli...

Open access Research Article 10.9734/jpri/2020/v32i930538