The acute toxicity of chloroform extract of Artemisia maciverae Linn was studied in Swiss albino mice. The mice were randomly distributed into four groups of three animals each. The groups were respectively administered both intraperitoneally and orally chloroform extract of Arte...
Open access
Research Article10.9734/BJPR/2014/7865
The present investigation targets to develop a simple, specific, sensitive and accurate reverse phase high performance liquid chromatographic (RP-HPLC) method in human plasma for the estimation of metformin HCl and propranolol HCl from bulk drug and also from the marketed product...
Open access
Research Article10.9734/BJPR/2014/10826
Extracts of St. John’s Wort (Hypericum perforatum) are known to cause interactions with certain conventional drugs. Herein, we focus on two clinically relevant concepts. First, St. John´s Wort has been used by people of all ages as an herbal treatment for depression without medic...
Open access
Research Article10.9734/BJPR/2014/9602
Tolterodine is an antimuscarnic drug that is used for sympathetic treatment of urinary incontinence. Tolterodine modified release tablet, was investigated in rabbit for pharmacokinetic and in vitro–in vivocorrelation studies. Tablets were prepared and in vitro release was studied...
Open access
Research Article10.9734/BJPR/2014/9950
Hypomagnesemia is one of the nephrotoxicity signs. In addition, renin-angiotensin system may be involved in pathophysiology of kidney diseases. Therefore, the present study was designed to investigate the possible role of losartan plus oral magnesium sulfate (MgSO4) to reduce CP-...
Open access
Research Article10.9734/BJPR/2014/10164
Aims: The present study compared the effects of metformin (met) and deferoxamine (DFX) on the hepatotoxic and nephrotoxic side effects of streptozotocin experimental diabetes in rats using serum biochemical and histopathological indicators. Study Design: Following induction of di...
Open access
Research Article10.9734/BJPR/2014/11812
This study assessed the erythropoietic effect of Eremomastax polysperma leaf extracts in female albino Wistar rats. Method: Twenty eight (28) female rats were divided into two major groups based on their weight and age. The duration of administration of E. polysperma extracts las...
Open access
Research Article10.9734/BJPR/2014/9603
Aims: A series of N,1-diphenyl-1,4-dihydrothiochromeno[4,3-c]pyrazole-3-carboxamide 5,5-dioxide derivatives (6a-m) were synthesized and evaluated for anticancer, antibacterial, and antifungal activity. Methodology: Reaction of 2,3-dihydro-4H-thiochromen-4-one 1,1-dioxide 2 with d...
Open access
Research Article10.9734/BJPR/2014/6155
A. M. Silva, B. Abrahim-Vieira, F. A. do Carmo, L. H. do Amaral, L. C. Silva, C. S. Escudini, M. A. Lopes, V. P. Sousa, H. C. Castro, F. Veiga, C. R. Rodrigues, A. J. Ribeiro & L. M. Cabral·Journal of Pharmaceutical Research International·2014
Aims: Develop an anti-tuberculosis (TB) Fixed Dose Combination (FDC) tablet containing an immediate release layer (IRL) composed of both rifampicin (RIF) and pyrazinamide (PYR) and a retarded release layer (RRL) comprised of isoniazid (INH) which would allow segregated delivery o...
Open access
Research Article10.9734/BJPR/2014/11525
Context: Extracellular glutamate level in reward centre of brain increases during ethanol drinking sessions. Hence, it can be hypothesized that drugs which decrease extracellular glutamate might have deaddictive properties. It has been shown that β-lactam antibiotics are potent s...
Open access
Research Article10.9734/BJPR/2014/9473
Aims: The purpose of this study was to investigate the antibacterial and antifungal properties of selected wild nutraceutical plants from Nebbi district in Uganda. Study Design: Experimental study. Place and Duration of Study: The study was carried out at the Department of Veteri...
Open access
Research Article10.9734/BJPR/2014/11443
Extraction and spectrophotometric determination of Uranium (VI) was carried out using Hydrazine Carboxamide-2-[(2-Hydroxy-1-Naphthalenyl) Methylene] as an analytical reagent. A reddish brown coloured complex is formed at pH 9.2 between U(VI):HCHNM which is extracted in n-butanol....
Open access
Research Article10.9734/BJPR/2014/7614
Nizam Uddin, Md. Rakib Hasan, Md. Monir Hossain, Md. Mahadi Hasan, Aumit Roy, Tufikul Islam, Md. Sazzad Hossain, Abdullah Faruque & Md. Sohel Rana·Journal of Pharmaceutical Research International·2014
Aims: To study and evaluate In vitro antioxidant, brine shrimp lethality and antimicrobial activities of both methanol and ethyl-acetate extracts of Citrus macroptera Montr. Fruit (Family-Rutaceae). Study Design: In vitro antioxidant, brine shrimp lethality and antimicrobial acti...
Open access
Research Article10.9734/BJPR/2014/11235
Laudelina R. de Magalhães, Iane Bezerra Vasconcelos Alves, Everaldo dos Santos, Vinícius Barros Ribeiro da Silva, Luiz Carlos Apolinário da Silva, Anekécia Lauro da Silva, Leidiane Carla Lira de Oliveira, Anne Cecília Nascimento da Cruz, Bruno Iraquitan Miranda da Silva, Lúcia Fernanda C. da Costa Leite, Marcelo Hernani Zaldini, Ivan da Rocha Pitta, Teresinha Gonçalves da Silva & Maria do Carmo Alves de Lima·Journal of Pharmaceutical Research International·2014
Aims: Evaluation of the anti-inflammatory properties of new thiazolidine-2,4-diones derivatives. Study Design: Study the effects of new thiazolidine-2,4-diones derivatives on the inflammatory process. Place and Duration of Study: Departamento de Antibióticos, Universidade Federal...
Open access
Research Article10.9734/BJPR/2014/11294
Aim: Allium cepa is consumed fresh or cooked in Nigeria and used as herb in ethno-medicinal practice against many ailments. The aqueous extract is used in the management of prostrate inflammation, alleviation of low sperm count and testicular damage related disorders in ethno med...
Open access
Research Article10.9734/BJPR/2014/10675