Heidi A. Dahlmann, Finn Beruldsen, Hayden L. Criswell, Phillip F. Crook, Evan C. Glassford, Alyssa K. Jones, Reece B. Mitchell, Laura F. Mortan, Nicholas Ryan, Alexandria M. Smith & Evan M. Vazquez·Organics·2026
Ring-closing carbonyl-olefin metathesis (COM) reactions provide a straightforward method for producing cyclic alkenes from precursors containing carbonyl functional groups tethered to nucleophilic alkenes. Within the last decade, many methods for carrying out Lewis acid- or organ...
Phenylglycine (Phg) is a nonproteinogenic α-amino acid found in various bioactive molecules. The C-terminal activation of N-acyl Phg is often accompanied by oxazolone-mediated racemization, arising from the direct attachment of the phenyl ring to the α-carbon. After peptide bond...
We have prepared two novel tethered (arene)Ru(II)/TsDPEN complexes, one containing a p-OTBS on the η6-arene ring, and the other with a p-CO2Et group at the same position, representing an electron-rich and electron-poor derivative. These have been evaluated in asymmetric transfer...
Anastasia R. Kovrizhina & Andrei I. Khlebnikov·Organics·2026
Ninhydrins represent a promising chemical space for the search for new biologically active molecules with antimicrobial, antiprotease, and antitumor properties. In the present work, new ninhydrin derivatives were synthesized, and for the first time, a systematic in silico study o...
Shai Ben Sasson, Noa Naama, Mikhail Kozlov, Ibrahim Amer & Moshe Portnoy·Organics·2026
Our recent studies demonstrated that dialkylaminopyridine organocatalysts featuring an extensive secondary sphere preferentially phosphorylate the alcohol at the apolar domain of a model amphiphilic diol. In the present study, this site-selective behavior was corroborated across...
Conventional oxidative hair dyes rely on aromatic amines, raising concerns about human health and environmental safety. This study reports a natural hair-coloring system using size-controlled ink particles (SIPs, ~170 nm in diameter) from cuttlefish ink and chitosan. Because both...
Xiumei Bai, Danila R. Chernyavskiy, Anna D. Maksimova, Ilya A. Yakushev, Viktor A. Tafeenko, Elena K. Beloglazkina & Alexander V. Finko·Organics·2026
We report the synthesis and single-crystal X-ray structures of three novel (Z)-5-arylidene-3-phenylrhodanine derivatives, differing in the substituents on the benzylidene fragment (two methoxy groups (compound I), a dioxine ring (compound II), or a dioxole ring (compound III)). D...
1,2,4-Trisubstituted chiral homoallylic alcohols are valuable intermediates in natural product synthesis and complex molecular architectures; however, their catalytic asymmetric synthesis remains challenging due to the need for precise control of regioselectivity, diastereoselect...
Andrea Navarrete-Mosquera, Juan Pedro Palomares-Báez, Rody Soto-Rojo, Tomás Delgado-Montiel, Samuel Soto-Acosta, Nora Aydee Sánchez-Bojorge, Daniel Glossman-Mitnik & Jesús Baldenebro-López·Organics·2026
This study presents a theoretical investigation of the adsorption and electronic structure of two imidazole derivatives, 4-(1,4,5-triphenylimidazol-2-yl)-aniline (M1) and N,N-dimethyl-4-(1,4,5-triphenylimidazol-2-yl)-aniline (M2), on an Fe(100) surface. A combined computational a...
Juozas Kiltinavičius, Kristina Kantminienė, Ilona Jonuškienė & Ingrida Tumosienė·Organics·2026
Reaction of 5-oxo-1-(4-(phenylamino)phenyl)pyrrolidine-3-carbohydrazide with selected aldehydes and ketone provided novel hydrazone derivatives bearing azole moieties: pyrazole, pyrrole, and indole. The drug likeness of the newly synthesized compounds and their physicochemical ch...