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Research Article Open access CC BY 4.0

Anti-diabetic, Anti-cancer Potential and Anti HIV of Bitter Gourd (Momordica charantia) Extract: A Mini Review

Manjoo Rani

Asian Plant Research Journal · pp. 66–77 · Published 17 Jul 2024

10.9734/aprj/2024/v12i4263

Abstract

Aims: To review the antidiabetic properties, pharmacological characteristics, and phytochemical research on Momordica Ccharantia (bitter gourd) and assess its potential as a therapeutic agent for diabetes and cancer prevention. Study Design: Review of existing literature and research studies, including pre-clinical trials and animal and in vitro studies. Methodology: Analysis of traditional uses, pharmacological data, and phytochemical research on M. Charantia. Evaluation of anti-diabetic and anti-HIV properties based on available studies. Results: • Charantia has shown anti-diabetic and hypoglycemic effects in pre-clinical studies. • Limited and unreliable clinical data due to poor research design and inadequate statistical power. • Recent studies indicate potential anti-tumor, anti-diabetic, and anti-HIV properties. • Plant extract components have demonstrated effectiveness in cancer prevention through immune function enhancement, induction of cell death, and inhibition of cancer-related processes. Conclusion: M. Charantia holds promise as a therapeutic agent for diabetes management and cancer prevention. However, there is a need for better-designed clinical trials to confirm its efficacy and establish reliable clinical evidence.

Momordica charantia antidiabetic properties traditional medicine cancer prevention

References (20)

  1. 1 Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency [DOI]
  2. 2 Anti-diabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review [DOI]
  3. 3 The effect of Momordica charantia capsule preparation on glycemic control in Type 2 Diabetes Mellitus needs further studies [DOI]
  4. 4 Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases [DOI]
  5. 5 The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo [DOI]
  6. 6 Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy [DOI]
  7. 7 A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia [DOI]
  8. 8 Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon [DOI]
  9. 9 New approach for extraction of charantin from Momordica charantia with pressurized liquid extraction [DOI]
  10. 10 Methanolic Extracts of Bitter Melon Inhibit Colon Cancer Stem Cells by Affecting Energy Homeostasis and Autophagy [DOI]
  11. 11 Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells [DOI]
  12. 12 Bitter gourd (Momordica charantia L.) seed oil as a naturally rich source of bioactive compounds for nutraceutical purposes [DOI]
  13. 13 A Review on Salient Pharmacological Features of Momordica charantia [DOI]
  14. 14 Emerging Antitumor Activities of the Bitter Melon (Momordica charantia) [DOI]
  15. 15 Analysis of Genetic Diversity and Population Structure in Bitter Gourd (Momordica charantia L.) Using Morphological and SSR Markers [DOI]
  16. 16 Evaluation of the efficacy of bitter gourd (momordica charantia) as an oral hypoglycemic agent--a randomized controlled clinical trial.
  17. 17 Bitter Gourd (Momordica charantia): A Dietary Approach to Hyperglycemia [DOI]
  18. 18 Medicinal and nutritional importance of bitter melon ( Momordica charantia L): A review article
  19. 19 Bitter Melon: A Multifunctional Medicinal Plant with Powerful Bioactive Compounds [DOI]
  20. 20 Better bitter gourd: a food-based approach to manage type 2 diabetes and promote health in developing countries [DOI]

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