Phytochemical Identification and Analgesic Potential of the Seed Extract of Irvingia gabonensis
Emmanuel Eimiomodebheki Odion, Philip Akugbe Obarisiagbon, Henrietta Erhuvwu Akpofure, Eravweroso Congrat Odiete
Asian Journal of Applied Chemistry Research · pp. 34–42 · Published 31 Dec 2022
10.9734/ajacr/2022/v12i4230Abstract
Different parts of Irvingia gabonensis are used ethno-medicinally in some West Africa culture in the treatment of pain. The stem bark has been reported in the literature to possess analgesic property. In order to evaluate the analgesic potential of the seed extract and the phytochemicals that may be responsible for this effect. This study was aimed at determining the phytochemical contents and the analgesic effect of I. gabonensis. The seed was screened for phytochemicals using standard procedures and GC-MS analysis. It central and peripheral analgesic potentials were evaluated at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg using acetic acid induced abdominal writhing and hot plate methods in Swiss albino mice. Acetylsalicylic acid (100 mg/kg), morphine hydrochloride (2 mg/kg) and pentazocine (15 mg/kg) were used as the standard drugs. ANOVA was used to analyze data from the results and level of significance was set at P ≤ 0.05. Phytochemical screening showed the presence of alkaloid, flavonoid, cardiac glycoside, triterpenoid and saponin. GC-MS analysis revealed thirty compounds mostly fatty acids. At 200 mg/kg of the methanolic extract, there was a dose dependent decrease in writhing response which also compared well with acetylsalicylic acid. From the results, Irvingia gabonensis seed contains compounds that could be responsible for the precieved analgesic activity.
References (22)
- 1 ACETIC ACID FOR ANALGESIC SCREENING
- 2 THE EVALUATION OF THE ANALGESIC ACTION OF PETHIDINE HYDROCHLORIDE (DEMEROL) [DOI]
- 3 Individual NSAIDs and Upper Gastrointestinal Complications [DOI]
- 4 Natural anti-inflammatory agents for pain relief [DOI]
- 5 Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats [DOI]
- 6 The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon [DOI]
- 7 Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial. [DOI]
- 8 Free radical scavenging activity, phenolic contents and cytotoxicity of selected Nigerian medicinal plants [DOI]
- 9 The Role of Vitamin E in Preventing and Treating Osteoarthritis – A Review of the Current Evidence [DOI]
- 10 Unsaturated Fatty Acids and Pain [DOI]
- 11 Anti-inflammatory and Antinociceptive Effects in Rodents of the Essential Oil of Croton cajucara Benth [DOI]
- 12 Ultra High-Performance Liquid Chromatography with High-Resolution Mass Spectrometry Analysis of African Mango (Irvingia gabonensis) Seeds, Extract, and Related Dietary Supplements [DOI]
- 13 Neuropharmacological effects of triterpenoids
- 14 Studies on the effects of microbial fermentation on bush mango (Irvingia gabonensis) seed cotyledons [DOI]
- 15 Identification of Compounds in Elaeis guineensis Fruits using GC-MS [DOI]
- 16 The phytoconstituents and the comparative effects of aqueous extract of Irvingia gabonensis seeds and proviron on the biochemical parameters of male guinea pigs [DOI]
- 17 A Novel Extraction Method and Some Physicochemical Properties of Extractives of Irvingia Gabonensis Seeds [DOI]
- 18 The Effect of Leaf Aqueous Extract of Brachystegia eurycoma Harms (Fabaceae) in Acute and Chronic Inflammatory Animal Models [DOI]
- 19 Drug discovery through ethnobotany in Nigeria: some results [DOI]
- 20 The Effect of Leaf Aqueous Extract of Brachystegia eurycoma Harms (Fabaceae) in Acute and Chronic Inflammatory Animal Models [DOI]
- 21 African Journal of Microbiology Research [DOI]
- 22 The key non-timber forest products of Central Africa: State of the knowledge
Cited by 3
Fidelia Okoben, InnocentMary Ejiofor, Ikechukwu Mbagwu · Sciences of Pharmacy · 2024
Showing 1 of 3 known citations — external sources report more than can currently be individually listed.
Related research
- Evaluation of the Antioxidant, Analgesic and Cytotoxic Activities of Daucus carota canopy L Ethanolic Extract — shares topic coverage
- Pharmacological Activities of Youngia japonica Extracts — shares topic coverage
- An Assessment of Analgesic & Anti-inflammatory Activity Spondias mombin and Mapping of Variation of Potency under the Light Geographical Contrast Based Phenomenon — shares topic coverage
- Phytochemical Screening, Anti-inflammatory and Analgesic Activities of Root Barks from Acacia macrostachya Reichenb. Ex DC. (Fabaceae) — shares topic coverage
- Anti-inflammatory and Analgesic Activities of the Methanolic Extract and the Residual Fraction of the Stem Bark of Daniellia oliveri (Fabaceae) — shares topic coverage
Article metrics
Real usage data collected on this platform.
8
Page views
0
PDF downloads
0
Outbound clicks
3
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.