Plasma 25-Hydroxy Vitamin-D and Risk of Breast Cancer: A Case Control Study
Salman Yousuf Guraya, Abdu Hassan Alzobydi, Shaista Salman Guraya
Journal of Advances in Medicine and Medical Research · pp. 508–515 · Published 29 Sep 2011
10.9734/BJMMR/2011/741Abstract
Objective: To evaluate the association between low serum levels of 25 (OH)2 D and the risk of breast cancer among the female population. Methods: A prospective case control study was done, which recruited female patients with newly diagnosed breast cancer, follow up cases of treated breast cancers, and recurrent or metastatic breast cancer (Group A). Another group of control volunteers, presenting with benign breast diseases, in the surgical clinics was incorporated (Group B). Serum vitamin D levels of both groups were compared. Results: 50 patients were included in each group. Age ranged 21-76 years with a mean of 47.6 years. The levels of vitamin D in Group A were significantly lower than those in Group B (Odd ratio 55.5); two-tailed p value <0.05. This signified a substantial difference of vitamin D levels between the patients with established breast cancer and those not suffering from breast cancer. Conclusion: There is significant relation between breast cancer disease and low levels of vitamin D. This finding testifies the hypothesis that low serum levels of vitamin D plays an important role in the pathogenesis of breast cancer.
References (30)
- 1 Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial [DOI]
- 2 Effect of four monthly oral vitamin D 3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial [DOI]
- 3 Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men [DOI]
- 4 The Role of Vitamin D in Cancer Prevention [DOI]
- 5 Calcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer [DOI]
- 6 The epidemiology of vitamin D and cancer incidence and mortality: A review (United States) [DOI]
- 7 Calcium Plus Vitamin D Supplementation and the Risk of Breast Cancer [DOI]
- 8 Intake of Dairy Products, Calcium, and Vitamin D and Risk of Breast Cancer [DOI]
- 9 Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D and Risk of Breast Cancer [DOI]
- 10 Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination Survey.
- 11 New insights into the mechanisms of vitamin D action [DOI]
- 12 Vitamin D3 from sunlight may improve the prognosis of breast-, colon- and prostate cancer (Norway) [DOI]
- 13 Intakes of Calcium and Vitamin D and Breast Cancer Risk in Women [DOI]
- 14 Cancer survival is dependent on season of diagnosis and sunlight exposure [DOI]
- 15 Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study [DOI]
- 16 Adolescent diet and risk of breast cancer [DOI]
- 17 Effect of Added Dietary Calcium on Colonic Epithelial-Cell Proliferation in Subjects at High Risk for Familial Colonic Cancer [DOI]
- 18 Dairy, Calcium, and Vitamin D Intake and Postmenopausal Breast Cancer Risk in the Cancer Prevention Study II Nutrition Cohort [DOI]
- 19 Anti-tumor activity of calcitriol: pre-clinical and clinical studies [DOI]
- 20 Vitamin D-3 Receptor as a Target for Breast Cancer Prevention [DOI]
- 21 Ecologic Studies of Solar UV-B Radiation and Cancer Mortality Rates [DOI]
- 22 Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk [DOI]
- 23 Effects of dietary fat, calcium, and vitamin D on growth and mammary tumorigenesis induced by 7,12-dimethylbenz(a)anthracene in female Sprague-Dawley rats.
- 24 Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women’s Health Study [DOI]
- 25 Intake of vitamin D and risk of breast cancer—A meta-analysis [DOI]
- 26 Acid haze air pollution and breast and colon cancer mortality in 20 Canadian cities.
- 27 Solar radiation, vitamin D and survival rate of colon cancer in Norway [DOI]
- 28 Prediagnostic Serum Vitamin D and Breast Cancer [DOI]
- 29 Prevention of N-Methyl-N-Nitrosourea-Induced Mammary Carcinogenesis in Rats by 1alpha-Hydroxyvitamin D5 [DOI]
- 30 Vitamin D Adequacy: A Possible Relationship to Breast Cancer [DOI]
Cited by 4
Shaista S. Guraya, Khadijah A. Alhussaini, Faten M. Shaqrun · Journal of Taibah University Medical Sciences · 2017
SalmanYousuf Guraya · Journal of Microscopy and Ultrastructure · 2014
Showing 2 of 4 known citations — external sources report more than can currently be individually listed.
Related research
- Reproductive Factors Associated with the Risk of Breast Cancer among Malaysian Women: A Multi-Centre Case-Control Study — shares topic coverage
- Factors Predicting the Utilization of Breast Cancer Screening Services among Women Working in a Private University in Ogun State, Nigeria — shares topic coverage
- Breast Cancer Screening Trend Year 2017 among South-Western Nigeria Female Residents — shares topic coverage
- Complementary Medicine Intervention in Breast Cancer Patients with Pain — shares topic coverage
- Breast Cancer Knowledge and Mammography Uptake among Women Aged 40 Years and Above in Calabar Municipality, Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
8
Page views
0
PDF downloads
0
Outbound clicks
4
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.