Transmission Blocking of Year Round Resistant Malaria in Koraput (India) by OMARIA – A New Antimalarial Phytotherapy
Deepak Bhattacharya, B. M. Bhuyan, P. K. Pradhan, D. K. Nayak
Journal of Pharmaceutical Research International · pp. 54–77 · Published 19 Dec 2012
10.9734/BJPR/2013/2207Abstract
Background: Globally, in resistant malaria endemic zones, even the latest lines of MDTs (multi drug therapes) are yielding chaotic results. These include unacceptable side effects/contraindications, with poor prognosis in juveniles/adolescents. Juvenile stage is intensely humoral and up-regulate infestation. MDTs are more unpredictable in the juveniles, and fail in the geriatric group. Pharmacies are also failing. Tropical-equatorial conditions necessitate frugal body cover cum bare foot life style. Typical geomorphology, orography, meteorology, flora and fauna provide year round conducive conditions for vector bionomics and for other types of infections. OMARIA (Orissa Malaria Research Indigenous Attempt) is a new anti-malaria phytotherapy that has been in mono station use (Koraput, India) since 1998 in drug resistant core endemic regions, also well known for tertian type. It transpired out of Koraput Model to Fight Malaria at Home with OMARIA. Materials and Methods: OMARIA is composed of the dry rind of the Indo-year round fruiting Punica granatum (Dalimba). Principal drug moieties are: (i) ellagic acid; (ii) punicalagin (iii) punicalin and (iv) potassium (K+). Are physiologically compatible and has never been used before. All the moieties being non alkaloids offer a paradigm shift among anti-malarials. Results: OMARIA kills and clears hemoprotozoas of all spp., at all stages (including gametocytes) in patients of all ages and chronicity. Is potently anti-inflammatory vis-a-vis WBCs; blocks transmission; prevents relapse and non- recrudescence; and is very useful in severe/acute/complicated/refractory malaria and in sickle cell patients. No development of resistance. Potassium (K+) probably acts as the drug’s efficacy upregulator. Conclusion: OMARIA is prophylactic and therapeutic in target groups. Is useful in numerous forms of malaria, being active against key stages of the parasite (complicated or systemic status); and in patients having multiple infections. It has synergistic and possibly buffering roles. Koraput Model has been of much help to the afflicted communities and to the administrations.
References (23)
- 1 Gray's Manual of Botany. [DOI]
- 2 Compendium of Indian medicinal plants
- 3 An Autobiography: The Story of My Experiments with Truth [DOI]
- 4 The silent path to thousands of merozoites: the Plasmodium liver stage [DOI]
- 5 Antioxidant, Antimalarial and Antimicrobial Activities of Tannin-Rich Fractions, Ellagitannins and Phenolic Acids from Punica granatum L. [DOI]
- 6 Intravital Observation of Plasmodium berghei Sporozoite Infection of the Liver [DOI]
- 7 Adult and child malaria mortality in India: a nationally representative mortality survey [DOI]
- 8 Pomegranate Juice and Extracts Provide Similar Levels of Plasma and Urinary Ellagitannin Metabolites in Human Subjects [DOI]
- 9 President's Malaria Initiative
- 10 Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events [DOI]
- 11 Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria [DOI]
- 12 Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes? [DOI]
- 13 Mutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure [DOI]
- 14 In vitro assessment of drug resistance in Plasmodium falciparum in five States of India.
- 15 Caspase-12 Dampens the Immune Response to Malaria Independently of the Inflammasome by Targeting NF-κB Signaling [DOI]
- 16 Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition [DOI]
- 17 Temporal trends in severe malaria in Chittagong, Bangladesh [DOI]
- 18 Medical Herbalism and Herbal Clinical Research: A Global Perspective [DOI]
- 19 Malaria in Koraput district of Orissa [DOI]
- 20 The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum [DOI]
- 21 Indian Anti-Malaria OMARIA Is Effective Against African Drug Resistant P. falciparum Field Isolates and Laboratory Strains; without Toxicity [DOI]
- 22 Anti-Malarial Drugs.
- 23 ENLARGEMENT OF THE THYROID GLAND IN MALARIA [DOI]
Cited by 17
Oluwatosin Kudirat Shittu, Musili Eyihuri Abubakar · International Journal of TROPICAL DISEASE & Health · 2015
`Saganuwan Alhaji Saganuwan, Patrick Azubuike Onyeyili · International Journal of TROPICAL DISEASE & Health · 2014
E. A. Nwoke, S. N. O. Ibe, U. M. Chukwuocha, B. O. Nworuh, C. I. C. Ebirim · International Journal of TROPICAL DISEASE & Health · 2014
Deepak Bhattacharya · Open Access Journal of Translational Medicine & Research · 2018
Maitreya Maity, Dhiraj Dhane, Tushar Mungle · Journal of Medical Systems · 2017
Pierre Lutgen · Pharmacy & Pharmacology International Journal · 2018
Showing 6 of 17 known citations — external sources report more than can currently be individually listed.
Related research
- Menopause-Related Domestic Violence in Bangladesh and Its Associated Factors — shares topic coverage
- Thyroid Status, Renal Profile and Electrolytes in Postmenopausal Women — shares topic coverage
- Mammographic Breast Pattern in Postmenopausal Women in Ibadan, South-Western Nigeria — shares topic coverage
- The Effect of Long-term Aerobic Exercises on Autonomic Imbalance in Postmenopausal Women — shares topic coverage
- Sex Hormones and Their Relationship with Leptin and Cardiovascular Risk Factors in Pre and Post-Menopausal Nigerian Women with Metabolic Syndrome — shares topic coverage
Article metrics
Real usage data collected on this platform.
37
Page views
0
PDF downloads
1
Outbound clicks
17
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.