Aims: Screening total alkaloidal extract from Alstonia boonei root bark for antimicrobial and wound healing activity. Methodology: The anti-microbial screening was performed using the agar well diffusion method and the excision wound model was employed for the wound healing exper...
Open access
Research Article10.9734/BJPR/2014/13952
Background: Silver nanoparticles (SNPs) rapid involvement in industry and nanomedicine increased human exposure to variable forms of these particles, with possible potential risk on human health. Aims: The aim of this study is to investigate the biochemical changes induced by var...
Open access
Research Article10.9734/BJPR/2014/14666
Aims: Metformin Hydrochloride, a biguanide, is an orally active antihyperglycemic agent, used in the treatment of non-insulin dependent diabetes mellitus (NIDDM). It has relatively short plasma half life, low absolute bioavailability. Extended release formulation of Metformin Hyd...
Open access
Research Article10.9734/BJPR/2014/14013
Objective: To investigate the anti-diarrhoea property of aqueous leaves extract of Psidium guajava (red apple guava leaves) in castor oil-induced diarrhoea in rats. Methods: Five groups of five rats each orally received the following treatment; groups II, III & IV received 10...
Open access
Research Article10.9734/BJPR/2014/13297
Biomedical investigations still rely on the use of laboratory animals, mice and rats are the most commonly used on experimentations. Past experimentations with these animals showed that they could be affected by environmental conditions and infections, causing interferences on re...
Open access
Research Article10.9734/BJPR/2014/14294
Aim: The application of factorial experimental design to evaluate the effect of particle size, capsule surface coating and binder concentration on the in vitro controlled release profile of metronidazole from encapsulated granules. Methodology: Metronidazole granules were prepare...
Open access
Research Article10.9734/BJPR/2014/7076
Objective: The aim of the present study was to investigate the antidiabetic potential of Pergularia daemiamethanolic extract (PD) on alloxan-induced diabetic mice. Methods: Diabetes was induced using alloxan (150mg/kg). Different doses of the methanolic extract of P. daemia were...
Open access
Research Article10.9734/BJPR/2014/13101
Introduction: Kwatha (decoction) preparations are one among commonest practiced Ayurvedic dosage forms, which are highly effective, but they are to be used when freshly prepared due to short shelf life (i.e. 1/2- 1 day), and they are often overlooked due to the preparation method...
Open access
Research Article10.9734/BJPR/2014/12978
Aims: Emblica officinalis, locally known as Amla, is a highly nutritious seasonal fruit. The processed fruit could be an important dietary source of natural vitamin C with potent antioxidant activity. The aim of present investigation was to study factors influencing antioxidant p...
Open access
Research Article10.9734/BJPR/2014/6643
Aim: This paper analyses the global and European responses to the break out of the H1N1 virus in 2009 and highlights the major deficiencies of the European authorization procedure of vaccines against H1N1 pandemic flu. Study Design: The study analyses the institutional reactions...
Open access
Research Article10.9734/BJPR/2014/12966
Stefano Rusconi, Roberta Gagliardini, Felicia Stefania Falvella, Dario Cattaneo, Valentina Di Cristo, Andrea De Luca, Massimiliano Fabbiani, Emilio Clementi, Massimo Galli & Simona Di Giambenedetto·Journal of Pharmaceutical Research International·2014
Background: Atazanavir, an antiretroviral drug of the protease inhibitor class, is co-administered with ritonavir to inhibit atazanavir metabolism and decrease pharmacokinetic variability. Atazanavir is metabolised mainly by CYP3A4/5 enzymes. High CYP3A intersubject variability h...
Open access
Research Article10.9734/BJPR/2014/14348
Aims: The study was designed to investigate cytotoxic and anthelmintic activity of aerial parts of Luffa acutangula (L.) Roxb. (Family: Cucurbitaceae, locally known as ‘Jhinga’), Luffa aegyptiaca Mill. (Family: Cucurbitaceae, locally known as ‘Dhundul’) and Momordica cochinchinen...
Open access
Research Article10.9734/BJPR/2014/4613
Aims: This study was undertaken to compare the quality and efficacy of six brands of antibacterial discs that are commercially available in Nigeria. Methodology: The brands evaluated include two foreign brands (Oxoid and Abtek) and four local brands (Optudisc, Polydisc, Maxidisc...
Open access
Research Article10.9734/BJPR/2014/10900
Aims: To ascertain the hematinic potential and bioactive compounds in Gossypium barbadense. Place and Duration of Study: Department of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, and Department of Applied Science, College of Science and Technology, Kaduna Polytechnic...
Open access
Research Article10.9734/BJPR/2014/13194
Aim: The aim of this work was to investigate the correlation between anti drug antibody (ADA) induction and how different manufacturing processes of biopharmaceuticals affect the immunogenicity of the protein. This was done by testing four different batches of the same recombinan...
Open access
Research Article10.9734/BJPR/2014/10923