Drug-induced Acute Kidney Injury (AKI) constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Drug-induced acute renal failure (ARF) accounted for 20% of all ARF in an Indian study. The incidence and prevalence of chroni...
Open access
Research Article10.9734/BJPR/2014/13446
Aim: Many medicinal plants have been used traditionally in treating ailments in humans and animals. However, for most of herbal remedies, no scientific toxicity profiles exist in literature. In this study, the safety profile of an herbal extract mixture containing Entada leptosta...
Open access
Research Article10.9734/BJPR/2014/10993
Mayara T. Pinheiro, Nayara S. R. Silva, Cleison C. Lobato, Francinaldo S. Braga, César F. Santos, Josivan S. Costa, José Carlos T. Carvalho & Cleydson Breno R. Santos·Journal of Pharmaceutical Research International·2014
Aims: The aims of the study were to evaluate alterations caused by the oral administration of the aqueous extract of Euterpe oleracea to non-isogenic adult male mice during 15 and 30 consecutive days through the comparison of body and spleen weights, number of splenic and medulla...
Open access
Research Article10.9734/BJPR/2014/10354
This study aimed at the investigation of piroxicam-niosomal hydrogel for ocular targeting to prolong and enhance its local analgesic activity. Various formulations were prepared, characterized and evaluated ex vivo for their transocular permeation using excised cow cornea. The pr...
Open access
Research Article10.9734/BJPR/2014/13723
Lucia Montenegro, Adriana Trapani, Paola Fini, Delia Mandracchia, Andrea Latrofa, Nicola Cioffi, Laura Chiarantini, Giusi Giada Picceri, Serena Brundu & Giovanni Puglisi·Journal of Pharmaceutical Research International·2014
Aims: The aim of this study was to explore the potential of novel nanoparticles (NPs) intended for topical administration of the hydrophilic antioxidant Glutathione and the lipophilic Idebenone. Glutathione was introduced into the NPs using two approaches: i) covalently bonded to...
Open access
Research Article10.9734/BJPR/2014/8641
This study was aimed at determining the effect of hyperglycaemia and glysuria on the antimicrobial susceptibility of pathogens isolated in UTI. 236 patients visiting the out-patient department of University of Uyo Health Centre presenting with symptoms of urinary tract infection...
Open access
Research Article10.9734/BJPR/2014/11205
Aim: Letrozole, a non-steroidal aromatase inhibitor, prevents the body from producing its own estrogen. The objective of the present study was to explore the fabrication and evaluation of natural biodegradable polymeric Letrozole implant for long term drug release targeting postm...
Open access
Research Article10.9734/BJPR/2014/12432
Aim: The aim of the present investigation was to enhance the dissolution rate of a poorly water soluble drug, aprepitant, by preparation of solid dispersion with hydrophilic carrier, poloxamer 188, using solvent evaporation method. Place and Duration of Study: Department of Pharm...
Open access
Research Article10.9734/BJPR/2014/10561
Aim: The effect of Ethanol Leaf Extract of Moringa oleifera (ELMO) on uterine smooth muscles of non- pregnant female rats was studied in vitro with a view to finding out the mechanism(s) for observed effects. Experiential Design: In vitro studies using isolated rat’s uteri. Metho...
Open access
Research Article10.9734/BJPR/2014/12140
Carlos Roberto Porto Dechandt, Damiana Luiza Pereira De Souza, Juliany Torres Siqueira, Mayara Peron Pereira, Renata Pires De Assis, Virginia Claudia Da Silva, Paulo Teixeira De Sousa Junior, Iguatemy Lourenço Brunetti, Claudia Marlise Balbinotti Andrade, Nair Honda Kawashita & Amanda Martins Baviera·Journal of Pharmaceutical Research International·2014
Aims: The study investigated the in vivo antioxidant activity and the in vitro radical scavenging capacity of the Combretum lanceolatum Pohl (Combretaceae) flowers ethanolic extract (ClEtOH) in streptozotocin-diabetic rats. Place and Duration of Study: Department of Chemistry, Fe...
Open access
Research Article10.9734/BJPR/2014/13558
Aims: The purpose of this study was to investigate the antibacterial and anticandidal activities of new flavonoids from Streptomyces sp. HK17 which was isolated from the root tissue of Curcuma longa Linn. Study Design: Experimental study. Place and Duration of Study: The study wa...
Open access
Research Article10.9734/BJPR/2014/13326
The reversed-phase high performance liquid chromatography (RP-HPLC) and high performance thin layer chromatography (HPTLC) methods for simultaneous estimation of Metfomin Hydrochloride (MET) and Vildagliptin (VLD) in bulk and their marketed combined dosage form were developed. Fo...
Open access
Research Article10.9734/BJPR/2014/12820
Aim: A new reverse phase high performance liquid chromatography (RP-HPLC) method for the quantitative determination of Esomeprazole and Naproxen in human plasma was developed and validated as per US-FDA guidelines. Methodology: The drug was spiked in the plasma and extracted with...
Open access
Research Article10.9734/BJPR/2014/10918
Aims: To identify stress and post traumatic stress symptoms (PTSS) in HIV patients on Antiretroviral therapy (ART) and further assess the possible relationship between stress, PTSS, immune function and ART medication adherence. Methods: After obtaining written informed consent, 1...
Open access
Research Article10.9734/BJPR/2014/13278