Aims: A novel nanocarrier was formulated by remote loading of doxorubicin (Dox) into a dipalmitoylphosphatidylcholine (DPPC) liposome that also contains various perfluorocarbon (PFC) droplets within its aqueous interior. It was shown that Dox can be loaded to a level of up to 67%...
Open access
Research Article10.9734/BJPR/2014/13143
Background: Japanese Kampo medicine, ninjinyoeito (NYT), is used for the treatment of complaints in patients with general fatigue, anorexia and anemia, and is recently applied in patients with chronic hepatitis C. However, there is little scientific evidence to demonstrate the li...
Open access
Research Article10.9734/BJPR/2014/13301
A. A. Adedeji, J. Babirye, O. Nsooli, D. Kamowa, O. A. Tikare, A. G. Okoruwa, J. O. C. Ezeonwumelu, A. A. Ganiyu, C. P. Adiukwu, J. Namulema, C. Barigye, S. Yusuf & M. Vicente-Crespo·Journal of Pharmaceutical Research International·2014
Aim: We investigated reporting of Adverse Drug Reaction (ADR) following use of drugs purchased from open system pharmacy (OSP) and drug stores, and the effectiveness of mobile phones for reporting drug reactions and detection of drug interactions. Study Design: The study was desc...
Open access
Research Article10.9734/BJPR/2014/8065
Aim: The aim of this study is to formulate a standard dose of aqueous extract of Moringa oleifera leaves into tablets and to determine a suitable binder for the formulation. Methodology: Aqueous extract of Moringa oleifera leaves was extracted and formulated using different binde...
Open access
Research Article10.9734/BJPR/2014/11516
Aims: The aim of the present study was to determine the effects of essential oil of wild Artemisia herba-alba grown in south Jordan on biofilm-forming bacteria. Study Design: Seven bacterial clinical isolates were used in this study. Biofilm formation was first quantified in micr...
Open access
Research Article10.9734/BJPR/2014/12605
Aims: Vaginal preparations are still associated with number of problems including frequent administration and escape from vagina causing discomfort to patient. For efficient vaginal delivery of drugs, the delivery system should reside at the site of infection for a prolonged peri...
Open access
Research Article10.9734/BJPR/2014/12089
Aim: Salacia lehmbachii is used in South Eastern Nigeria folk medicine to treat abdominal pain, inflammatory disorders and malaria symptom without scientific documentation. The aim of this study was therefore, to assess possible analgesic and anti-inflammatory activities of aqueo...
Open access
Research Article10.9734/BJPR/2014/9250
Objective: To evaluate antioxidant, analgesic and anti-inflammatory properties of embelin and its derivatives. Methods: In the present study embelin was condensed with various aliphatic substituted primary amines, hydrazines and amino acids to yield seven new and five reported de...
Open access
Research Article10.9734/BJPR/2014/12708
Aims: The ethanolic extracts of stem bark and fruit pulp as well as saponins from Dialium guineense were assayed for antibacterial activity against Gram positive and negative strains and clinical strains of methicilin resistant Staphylococcus aureus (MRSA) isolated from different...
Open access
Research Article10.9734/BJPR/2014/12943
Aims: This study evaluated the anxiolytic, sedative and hypothermic effects of aqueous leaf extract of Vernonia amygdalina in Mice. Study Design: One-factor two control groups experimental design. Place and Duration of Study: Department of Pharmacology, Faculty of Pharmacy, Obafe...
Open access
Research Article10.9734/BJPR/2014/12529
Rilson José do Pinho, Rafael Pazinatto Aguiar, Ricardo Alexandre Spironello, Francielli Maria de Souza Silva-Comar, Saulo Euclides Silva-Filho, Eurica Mary Nogami, Ciomar Aparecida Bersani-Amado & Roberto Kenji Nakamura Cuman·Journal of Pharmaceutical Research International·2014
Aims: Liver diseases have become one of the major causes of morbidity and mortality all over the world. This study investigated the hepatoprotective and antioxidant effect of rosemary essential oil (REO) and ginger essential oil (GEO), against paracetamol-induced liver damage. Me...
Open access
Research Article10.9734/BJPR/2014/13025
Persicaria odorata is a common plant and well known in Malaysia as “Daun kesum” that is commonly used in cuisines and has various medicinal properties. This study was conducted to investigate the antimicrobial activity and the extraction technique that produce the most active pla...
Open access
Research Article10.9734/BJPR/2014/12232
Aims: The present study was aimed at investigating the antidiabetic potentials of Combretum dolichopetalum root in alloxan-induced animals with the hope of isolating its antidiabetic principles. Study Design: Sixty four Wistar albino rats of either sexes were randomly segregated...
Open access
Research Article10.9734/BJPR/2014/9143
Aims: The ethanolic extract of Excoecaria agallocha stem bark was evaluated for antioxidant properties and quantification of bioactive polyphenols by HPLC-DAD. Methodology: ABTS assay, total antioxidant capacity, reducing power, total phenolic and flavonoid contents were used for...
Open access
Research Article10.9734/BJPR/2014/12425
Aims: In the present study, the crude methanol extract of tuber of Polianthes tuberosa Linn along with its all Kupchan fractions were investigated for antioxidant, cytotoxic, antimicrobial, membrane stabilizing and thrombolytic activities. Place and Duration of Study: The study w...
Open access
Research Article10.9734/BJPR/2014/12414