Aims: Highly Active Antiretroviral Therapy (HAART) is associated with metabolic complications. An unexpected extension of functional implications of melatonin, the neuro-hormone synthetized during the night, has been reported on the development of type 2 diabetes, sleep disturban...
Open access
Research Article10.9734/bjpr/2016/29474
Omeprazole (OPZ) efficiently suppresses acid secretion in the parietal cells of the stomach. It is widely recommended as proton pump inhibitor (PPI) in Egypt. Presence of many products containing omeprazole available in the Egyptian market raises questions of generic substitution...
Open access
Research Article10.9734/bjpr/2016/29952
Aim: Morus mesozygia is a specie of the Morus family in Africa that is traditionally used for the treatment of rheumatism. Until this moment, there is no available literature on the scientific evidence of the in vivo anti-inflammatory effects. The aim is to determine the safety o...
Open access
Research Article10.9734/bjpr/2016/28746
The focus of this research work was to develop a melt granulation technique to enhance solubility, dissolution rate and associated flowability concerns of Ibuprofen. Hydrophilic excipients like xylitol and lactose anhydrous were added to the binary mixture of conventional low mel...
Open access
Research Article10.9734/bjpr/2016/29048
Endothelin-1 (ET-1) is predominantly expressed in endothelial cells to modulate physiological actions, such as vasoconstriction and cell proliferation. It acts as an autocrine and paracrine factor, and has been reported to be found in increased levels in the blood of patients wit...
Open access
Research Article10.9734/bjpr/2016/29824
Two methods were developed for simultaneous determination of triclabendazole and ivermectin, in addition to a Vis-spectrophotometric method for the analysis of ivermectin only. The first one was HPLC method in which efficient separation of two drugs was achieved on a C18 column w...
Open access
Research Article10.9734/bjpr/2016/29196
Aims: This study was undertaken to evaluate the effectiveness of behavioral modulation of C. cassia extract against Haloperidol induced Parkinson’s disease (PD) in albino mice. Study Design: The study used animal models to test the effect of Haloperidol in development of PD and e...
Open access
Research Article10.9734/bjpr/2016/29286
Odontonema is a group of tropical plant species used in folklore medicine because of its wide range of pharmacological properties. These plants are known to be anti-bacterial, anti-inflammatory, anti-hypertensive, anti-viral, hepatoprotective, sedative and anti-oxidant. Furthermo...
Open access
Research Article10.9734/bjpr/2016/29877
Self-medication involves the use of medicinal products by the individuals to treat self-recognized diseases or symptoms or the intermittent or continuous use of medication prescribed by a physician for chronic or recurrent disease or symptoms. Self-medication also involves acquir...
Open access
Research Article10.9734/bjpr/2016/30333
Background: Penisetum glaucum is one of the earliest indigenous food crops in East Africa. Pearl millet contains numerous phytocompounds. Isolation and characterization of secondary metabolites from pearl millet and evaluation of their bioactivity is necessary. These will act as...
Open access
Research Article10.9734/bjpr/2016/28434
Objective: To determine the infective dose of Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853) in Sprague Dawley rats, when the inoculum is injected via the intraperitoneal route. Design and Methods: In interest of animal welfare and to reduce the number...
Open access
Research Article10.9734/bjpr/2016/29932
Aims: To perform anti-microbial activity guided isolation and to characterize compound(s) from fruit pulp (extracts) of Azanza garckeana. Place and Duration of Study: Department of chemistry, University of Agriculture, Makurdi, Nigeria, and University of Strathclyde in Scotland,...
Open access
Research Article10.9734/bjpr/2016/30152
Background: Alchornea laxiflora is a medicinal plant with immense health benefits. Aim: To verify the protective effects of methanol extract of Alchornea laxiflora (MEAL) leaf on hepatotoxicity and reproductive toxicity induced by CCl4. Settings and Design: Extraction and adminis...
Open access
Research Article10.9734/bjpr/2016/29807
Aim: To prevent proliferation of mosquito borne diseases, to improve quality of life, mosquito control is essential. Research was aimed to find alternative eco-friendly and bio-degradable strategies in mosquito control at the larvae stage. Hence an attempt was made to study the l...
Open access
Research Article10.9734/bjpr/2016/29878
Several pathogenic bacteria are developing antibiotic resistance. Recovery from multidrug resistant (MDR) infections is a problematic issue and requires a multiple treatment with broad-spectrum antibiotics which are less effective, more toxic and more expensive. Silver nanopartic...
Open access
Research Article10.9734/bjpr/2016/30525